Document Detail

17 alpha-hydroxyprogesterone caproate versus intravaginal progesterone in IVF-embryo transfer cycles: a prospective randomized study.
MedLine Citation:
PMID:  15257811     Owner:  NLM     Status:  MEDLINE    
One of the main issues in the management of IVF and embryo transfer techniques is to ensure adequate concentrations of progesterone. The aim of this prospective, randomized study was to compare the effectiveness of 17 alpha -hydroxyprogesterone caproate (17-HPC) administered intramuscularly and intra-vaginal progesterone in gel in luteal phase support in patients undergoing IVF-embryo transfer cycles. A total of 320 patients were randomly treated with either 17-HPC (341 mg i. m. every 3 days) or progesterone vaginal gel (90 mg daily). The inclusion criteria were the use of gonadotrophin-releasing hormone down-regulation and age <40 years. The outcome of IVF in both study groups was evaluated for implantation rate, biochemical pregnancy, clinical pregnancy, miscarriage, and ongoing pregnancy rate. The results of this study showed that 17-HPC conferred more benefit to IVF-embryo transfer cycles compared with intra-vaginal progesterone, as demonstrated by the results of most of the main outcome parameters considered. The data showed that 17-HPC administered every 3 days appears to be more effective in providing luteal support in comparison to intra-vaginal progesterone.
Vittorio Unfer; Maria Luisa Casini; Loredana Costabile; Sandro Gerli; Domenico Baldini; G C Di Renzo
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  9     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-19     Completed Date:  2005-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
A. G. UN. CO, Obstetrics and Gynecology Centre, Via G. Cassiani, 15-00155 Rome, Italy.
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MeSH Terms
Administration, Intravaginal
Embryo Transfer*
Estradiol / blood
Fertilization in Vitro / methods*
Hydroxyprogesterones / administration & dosage*
Injections, Intramuscular
Luteal Phase / drug effects
Oocytes / physiology
Pregnancy Rate
Progesterone / administration & dosage*,  blood
Prospective Studies
Reg. No./Substance:
0/Hydroxyprogesterones; 50-28-2/Estradiol; 57-83-0/Progesterone; 630-56-8/17-alpha-hydroxy-progesterone caproate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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