Document Detail

17 alpha-hydroxyprogesterone caproate vehicle, castor oil, enhances the contractile effect of oxytocin in human myometrium in pregnancy.
MedLine Citation:
PMID:  20452486     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The possibility exists that the vehicle for 17-alpha-hydroxyprogesterone caproate, castor oil, exerts an effect on human uterine contractility. The aim of this study was to evaluate its effects on contractility of myometrial preparations that were obtained during pregnancy. STUDY DESIGN: Myometrial strips were suspended under isometric conditions. Contractility was induced with oxytocin. Strips were incubated in castor oil or physiologic salt solution and suspended for a further oxytocin challenge. Contractile integrals were compared between both groups. RESULTS: Strips that were exposed to castor oil demonstrated increased contractile activity that was elicited by oxytocin (mean contractility value, 165.53%+/-17.03%; n=8; P=.004), compared with control strips (mean contractility value, 72.57%+/-7.48%; n=8; P=.003). There was a significant increase in contractile activity of the castor oil-exposed strips, compared with those that were exposed to physiologic salt solution (n=8; P<.001). CONCLUSION: Exposure of human myometrial preparations to castor oil results in enhanced oxytocin-induced contractility.
Michael D O'Sullivan; Mark P Hehir; Yvonne M O'Brien; John J Morrison
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  202     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  453.e1-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Department of Obstetrics and Gynaecology, Clinical Science Institute, National University of Ireland Galway, Galway University Hospitals, Newcastle Road, Galway, Ireland.
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MeSH Terms
17-alpha-Hydroxyprogesterone / administration & dosage*
Castor Oil / administration & dosage*
Drug Synergism
Injections, Intramuscular
Oxytocin / physiology*
Pregnancy Trimester, Third / physiology
Uterine Contraction / drug effects*,  physiology*
Reg. No./Substance:
50-56-6/Oxytocin; 68-96-2/17-alpha-Hydroxyprogesterone; 8001-79-4/Castor Oil
Comment In:
Am J Obstet Gynecol. 2010 May;202(5):409-10   [PMID:  20452480 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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