Document Detail

17-Hydroxyprogesterone in premature infants as a marker of intrauterine stress.
MedLine Citation:
PMID:  18211251     Owner:  NLM     Status:  MEDLINE    
AIMS: Amniotic infection (AI) and preeclampsia (PE), which are commonly the reason for prematurity, inflict stress of different duration on immature fetuses. Whether chronic stress, as reflected by intrauterine growth retardation, influences the level of 17-OH progesterone (17-OHP), was not previously examined. METHODS: We analyzed 17-OHP and TSH levels during neonatal screenings in the first hours of life of 90 premature infants born between 25 and 33 weeks of gestation in infants with AI (n=37) or with PE (n=53). Control of acute stress parameters was derived from umbilical arterial cord blood pH and base excess (BE). RESULTS: Mean 17-OHP levels of infants born to mothers with PE were 85.7 nmol/L compared to 54.6 nmol/L (P<0.001) in AI infants. 17-OHP was even higher when intrauterine growth restriction was present (99.8 nmol/L). Antenatal steroids and mode of delivery did not significantly affect 17-OHP levels. CONCLUSIONS: Stress of relatively long duration, as in cases of PE, leads to a significant increase of 17-OHP level in preterm infants. The postnatal 17-OHP level may be considered as a measure for severity of intrauterine stress and might be used as an individualized indicator for earlier intensive care.
Jörg Ersch; Ernst Beinder; Thomas Stallmach; Hans Ulrich Bucher; Toni Torresani
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  36     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-07-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  IM    
Department of Neonatology, Zurich University, Switzerland.
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MeSH Terms
17-alpha-Hydroxyprogesterone / blood*
Biological Markers / blood
Chorioamnionitis / blood*
Fetal Growth Retardation / blood
Infant, Newborn
Infant, Premature / blood*
Pre-Eclampsia / blood*
Stress, Physiological / blood,  etiology
Thyrotropin / blood
Reg. No./Substance:
0/Biological Markers; 68-96-2/17-alpha-Hydroxyprogesterone; 9002-71-5/Thyrotropin

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