Document Detail


17-Hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats.
MedLine Citation:
PMID:  19733289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Reduction in uteroplacental perfusion (RUPP) in pregnant rats is associated with hypertension, elevated cytokines, and activation of the endothelin (ET-1) system. Our objective was to determine whether the antiinflammatory properties of 17-alpha-hydroxyprogesterone caproate (17 OHP) reduce cytokine-stimulated vasoactive pathways that are associated with hypertension in response to placental ischemia.
STUDY DESIGN: Mean arterial pressure (MAP), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and renal ET-1 were measured in the following: pregnant controls, pregnant controls plus 17 OHP (6.6 mg/kg), RUPP rats, and RUPP rats plus 17 OHP.
RESULTS: MAP increased 29 mm Hg in RUPP rats compared with pregnant controls (P < .001), whereas in RUPP plus 17 OHP rats, MAP increased only 19 mm Hg (P < .05). TNF-alpha and IL-6 increased 2- to 3-fold, respectively, in response to placental ischemia but was normalized in RUPP rats treated with 17 OHP. ET-1 increased 3-fold in RUPP rats but was markedly less in RUPP plus 17 OHP rats.
CONCLUSION: 17 OHP blunts hypertension associated with RUPP, possibly via suppression of cytokine-stimulated ET-1 activation.
Authors:
Edward W Veillon; Sharon D Keiser; Marc R Parrish; William Bennett; Kathy Cockrell; Lillian F Ray; Joey P Granger; James N Martin; Babbette LaMarca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  201     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-10-08     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  324.e1-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
17-alpha-Hydroxyprogesterone / pharmacology*
Animals
Endothelin-1 / physiology
Female
Hydroxyprogesterones / pharmacology
Ischemia / drug therapy,  physiopathology
Placenta / blood supply
Placental Circulation / drug effects*,  physiology*
Pregnancy
Progesterone Congeners / pharmacology
Rats
Tumor Necrosis Factor-alpha / blood
Grant Support
ID/Acronym/Agency:
F32 HL078147/HL/NHLBI NIH HHS; F32 HL078147-03/HL/NHLBI NIH HHS; R01 HL038499/HL/NHLBI NIH HHS; R01 HL038499-15/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endothelin-1; 0/Hydroxyprogesterones; 0/Progesterone Congeners; 0/Tumor Necrosis Factor-alpha; 630-56-8/17-alpha-hydroxy-progesterone caproate; 68-96-2/17-alpha-Hydroxyprogesterone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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