| 17β-Estradiol and Interferon Tau Interact in the Regulation of the Immune Response in a Model of Experimental Autoimmune Orchitis. | |
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MedLine Citation:
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PMID: 21787220 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Immunoregulatory activity of type I interferons (IFNs) and estrogen is convergent in some cases of autoimmune disorders. The aim of our study was to determine whether a potent interaction of IFN and estradiol (E2) has an influence on immune response and estrogen receptor alpha (ER-α) expression in antigen-presenting cells in a model of experimental autoimmune orchitis (EAO). C3H/He/W male mice were immunized with testicular germ cells (TGCs) and orally treated with interferon tau (IFN-τ), E2, or both simultaneously. The delayed-type hypersensitivity reaction was intensified after the administration of either IFN-τ or E2, but their co-administration had no effect. IFN-τ treatment increased immunoglobulin G2a (IgG2a) and decreased IgG1 levels of TGC-specific antibodies, whereas E2 abolished the effects of the used cytokine. The total splenic cellularity and the number of spleen CD11c+MHC II+ and F4/80+MHC II- cells were increased after IFN-τ treatment, whereas E2 antagonized this effect. After IFN-τ administration the level of ER-α was significantly higher in F4/80+MHC II- cells, whereas E2 had no effect. However, the administration of E2 significantly reduced the ER-α level in F4/80+MHC II+ and CD11c+MHC II+ cells in comparison with the IFN-τ-treated groups. In the EAO model, the type I IFN and E2 cooperated at the general and cellular levels of immune response, but E2 treatment usually abolished the effects exerted by the cytokine. |
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Authors:
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Tomasz Maj; Anna Sławek; Katarzyna Kaleta-Kuratewicz; Anna Chełmońska-Soyta |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-25 |
Journal Detail:
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Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: - ISSN: 1557-7465 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Laboratory of Reproductive Immunology, L. Hirszfeld Institute of Immunology and Experimental Therapy , Polish Academy of Sciences, Wrocław, Poland . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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