Document Detail

A 165 kd protein of the herpes simplex virion shares a common epitope with the regulatory protein, ICP4.
MedLine Citation:
PMID:  2476124     Owner:  NLM     Status:  MEDLINE    
We have investigated the possibility that immediate-early (IE) protein ICP4 could be a part of herpes simplex virus type 1 (HSV-1) virion particle. Immunodetection with a monoclonal antibody against ICP4 reveals that a component of the virion, migrating at 165 kd, shares a common epitope with this immediate-early protein. Immunolocalization studies on purified virions indicate that the antigen can be detected only in virions without membranes, and is located outside the capsid, most probably in the tegument. Ultrastructural localizations on HSV-1 infected BHK cells extracted with a nonionic detergent confirm that the protein immunoreacting with anti-ICP4 is present in virions.
V Bibor-Hardy; F Sakr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  163     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-06     Completed Date:  1989-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  124-30     Citation Subset:  IM    
Institut du Cancer de Montréal, QC, Canada.
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MeSH Terms
Antigens, Viral / immunology*
Capsid / immunology
Cell Line
Cytoskeleton / immunology
Immediate-Early Proteins*
Molecular Weight
Simplexvirus / immunology*,  ultrastructure
Viral Core Proteins / immunology
Viral Proteins / immunology*
Virion / immunology*
Reg. No./Substance:
0/Antigens, Viral; 0/Epitopes; 0/Immediate-Early Proteins; 0/Viral Core Proteins; 0/Viral Proteins; 0/herpes simplex virus, type 1 protein ICP4

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