Document Detail


16, 16 dimethyl PGE2: evidence that it has properties different from the parent compound in vascular smooth muscle.
MedLine Citation:
PMID:  7403339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
16, 16 dimethyl PGE2 (dmPGE2) differs from its parent compound, PGE2, in the way in which it affects vascular reactivity in the isolated perfused mesenteric vascular bed of the rat. Increasing concentrations of PGE2 progressively increase response amplitudes to both noradrenaline and potassium but have no effect on baseline pressure. PGE1 does not change potassium responses but has a biphasic effect on noradrenaline responses, increasing them at low concentrations and inhibiting them at high ones: it has no effect on baseline pressure. PG12 progressively inhibits noradrenaline responses but has no effect on potassium responses: it does not influence baseline pressure in this preparation. PGF2 alpha, like PGE2, enhances responses to both noradrenaline and potassium but, unlike PGE2, strongly elevates baseline pressure. dmPGE2 progressively enhanced responses to potassium, had a biphasic effect on responses to noradrenaline, and strongly raised baseline pressure. Its effects were therefore different from PGE2 and shared properties of the other PGs. This analogue must be used with caution as a guide to the physiological effects of PGE2 itself. The superior mesenteric preparation, which responds very differently to different PGs may be a valuable tool for determining the changes in properties brought about by manipulation of the parent PG molecules.
Authors:
A I Ally; D F Horrobin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins and medicine     Volume:  5     ISSN:  0161-4630     ISO Abbreviation:  Prostaglandins Med     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7810330     Medline TA:  Prostaglandins Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
16,16-Dimethylprostaglandin E2 / pharmacology*
Animals
Blood Pressure / drug effects
Male
Mesenteric Arteries / drug effects
Muscle, Smooth, Vascular / drug effects*
Norepinephrine / pharmacology
Perfusion
Potassium / pharmacology
Prostaglandins E / pharmacology
Prostaglandins E, Synthetic / pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Prostaglandins E; 0/Prostaglandins E, Synthetic; 39746-25-3/16,16-Dimethylprostaglandin E2; 51-41-2/Norepinephrine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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