| Is the [15N]methacetin liver function test suited to estimate environmental effects on the maturity of neonates? | |
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MedLine Citation:
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PMID: 7812247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical and paraclinical data of 91 neonates of the Saxon regions of Leipzig and of Torgau/Elbe were reviewed and correlated to the environmental conditions of the places of residence of their mothers during pregnancy. One of the parameters investigated was the hepatic detoxification capacity of the neonates measured by 15N elimination rates in the [15N]methacetin urine test. Because of heavy air pollution in the places of residence of some of the pregnant women, a distinct reflection of environmental influence in the parameters was expected. While some of the parameters considered, such as birth weight and bilirubin levels, did not correlate with mean exposure data of the residences of the pregnant women, the mean rate of the age-dependent maturation of hepatic 15N elimination did. This maturation was seen to be significantly decreased in heavily polluted districts of the Leipzig region compared to lower polluted places of Leipzig and to the lowly polluted region of Torgau/Elbe. |
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Authors:
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P Krumbiegel; L Stolz; O Herbarth; W Braun; G Boehm; S Kausch; A Wirsing |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Central European journal of public health Volume: 2 ISSN: 1210-7778 ISO Abbreviation: Cent. Eur. J. Public Health Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1995-02-08 Completed Date: 1995-02-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9417324 Medline TA: Cent Eur J Public Health Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 49-51 Citation Subset: IM |
Affiliation:
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Department of Human Exposure Research and Epidemiology, Center of Environmental Research, Leipzig-Halle. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetamides
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diagnostic use* Female Humans Infant, Newborn Infant, Small for Gestational Age Liver / metabolism* Maternal Exposure Nitrogen Isotopes* Pregnancy Regression Analysis Residence Characteristics Sensitivity and Specificity Sulfur Dioxide / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Acetamides; 0/Nitrogen Isotopes; 51-66-1/methacetin; 7446-09-5/Sulfur Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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