Document Detail

Is the [15N]methacetin liver function test suited to estimate environmental effects on the maturity of neonates?
MedLine Citation:
PMID:  7812247     Owner:  NLM     Status:  MEDLINE    
Clinical and paraclinical data of 91 neonates of the Saxon regions of Leipzig and of Torgau/Elbe were reviewed and correlated to the environmental conditions of the places of residence of their mothers during pregnancy. One of the parameters investigated was the hepatic detoxification capacity of the neonates measured by 15N elimination rates in the [15N]methacetin urine test. Because of heavy air pollution in the places of residence of some of the pregnant women, a distinct reflection of environmental influence in the parameters was expected. While some of the parameters considered, such as birth weight and bilirubin levels, did not correlate with mean exposure data of the residences of the pregnant women, the mean rate of the age-dependent maturation of hepatic 15N elimination did. This maturation was seen to be significantly decreased in heavily polluted districts of the Leipzig region compared to lower polluted places of Leipzig and to the lowly polluted region of Torgau/Elbe.
P Krumbiegel; L Stolz; O Herbarth; W Braun; G Boehm; S Kausch; A Wirsing
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Central European journal of public health     Volume:  2     ISSN:  1210-7778     ISO Abbreviation:  Cent. Eur. J. Public Health     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9417324     Medline TA:  Cent Eur J Public Health     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
Department of Human Exposure Research and Epidemiology, Center of Environmental Research, Leipzig-Halle.
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MeSH Terms
Acetamides / diagnostic use*
Infant, Newborn
Infant, Small for Gestational Age
Liver / metabolism*
Maternal Exposure
Nitrogen Isotopes*
Regression Analysis
Residence Characteristics
Sensitivity and Specificity
Sulfur Dioxide / adverse effects
Reg. No./Substance:
0/Acetamides; 0/Nitrogen Isotopes; 51-66-1/methacetin; 7446-09-5/Sulfur Dioxide

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