Document Detail

A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.
MedLine Citation:
PMID:  7887138     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH). MATERIAL AND METHODS-A 50-year-old woman was followed-up for 15 years clinically and paraclinically after a heavy PHT intoxication. Her immunoglobulins in serum were checked on PHT and after 15 years treatment with carbamazepine. RESULTS-A gross mass of hyperplasia tissue found primarily in the left side of her mouth had disappeared and serum IgA which was subnormal at the first visit had normalized. CONCLUSION-It is possible to prevent GH from PHT treatment by intensive dental care, correct mouth hygiene and by change of treatment of carbamazepine.
S Tigaran
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  90     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-04-13     Completed Date:  1995-04-13     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  IM    
Neurology Clinic, Hvidovre Hospital, Copenhagen, Denmark.
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MeSH Terms
Carbamazepine / administration & dosage
Cerebral Infarction / complications
Dose-Response Relationship, Drug
Epilepsies, Partial / blood,  drug therapy*
Follow-Up Studies
Gingival Hyperplasia / blood,  chemically induced*
Middle Aged
Oral Hygiene
Phenytoin / adverse effects*,  pharmacokinetics,  therapeutic use
Reg. No./Substance:
298-46-4/Carbamazepine; 57-41-0/Phenytoin

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