Document Detail

15-hydroperoxydehydroabietic acid--a contact allergen in colophony from pinus species.
MedLine Citation:
PMID:  7766387     Owner:  NLM     Status:  MEDLINE    
A new hydroperoxide, 15-hydroperoxydehydroabietic acid (15-HPDA), with contact allergenic properties has been detected in rosin obtained from Pinus species. Detection was facilitated using a synthetic preparation of 15-HPDA for reference purposes. The synthesis and the detection (HPLC and GC) of 15-HPDA in rosin are described. The allergenic activity of 15-HPDA was studied in an experimental sensitization test on guinea-pigs.
L P Shao; E Gäfvert; U Nilsson; A T Karlberg; J L Nilsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytochemistry     Volume:  38     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-06     Completed Date:  1995-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-7     Citation Subset:  B    
Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Stockholm, Sweden.
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MeSH Terms
Allergens / analysis*
Chromatography, Gas
Chromatography, High Pressure Liquid
Diterpenes / analysis*
Diterpenes, Abietane*
Guinea Pigs
Mass Spectrometry / methods
Phenanthrenes / analysis*
Trees / chemistry*
Reg. No./Substance:
0/15-hydroperoxydehydroabietic acid; 0/Allergens; 0/Diterpenes; 0/Diterpenes, Abietane; 0/Phenanthrenes; 0/methyl 15-hydroperoxydihydroabietate

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