Document Detail

15-Year review of laryngeal and oral dysplasias and progression to invasive carcinoma.
MedLine Citation:
PMID:  19543904     Owner:  NLM     Status:  MEDLINE    
The objective of this study is to identify a management or follow-up strategy for patients with laryngeal and oral dysplasia. A chart review of all patients with laryngeal and oral dysplasia over a 15-year period was performed. All patients were followed for a minimum period of 5 years from initial diagnosis of oropharyngeal or laryngeal dysplasia. If invasive carcinoma was demonstrated on subsequent biopsies, the exact time of this was recorded and Kaplan-Meier survival curves were plotted. In the laryngeal cohort, 45 patients were identified, 15 (33%) developed carcinoma, 7 of 30 patients (23%) with mild or moderate dysplasia, compared with 8 of 15 (53%) with severe dysplasia or CIS (P = 0.01). Thirteen of the carcinomas (87%) developed within 36 months of original biopsy. In the oral cohort, 32 patients were identified, 17 (53%) developed carcinoma, 1 of 9 patients (11%) with mild dysplasia, compared with 8 of 12 (67%) with severe dysplasia and 8 of 10 (80%) with CIS (P < 0.001). Fifteen of the 17 patients (88%) developed carcinoma within 36 months of original biopsy. In conclusion, although numbers are small, our results show that mild and moderate laryngeal dysplasia behaves differently to severe dysplasia and CIS. Mild oral dysplasia also behaves differently to severe dysplasia or CIS. In general, progress to malignancy happens within a 3-year period. Severe dysplasia or CIS should be managed aggressively.
Patrick M Spielmann; T Palmer; L McClymont
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Publication Detail:
Type:  Journal Article     Date:  2009-06-20
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  267     ISSN:  1434-4726     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  423-7     Citation Subset:  IM    
Department of Otolaryngology, Raigmore Hospital, Old Perth Rd, Inverness IV2 3UJ, UK.
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MeSH Terms
Aged, 80 and over
Carcinoma in Situ / pathology*
Carcinoma, Squamous Cell / pathology*
Cohort Studies
Disease Progression
Follow-Up Studies
Kaplan-Meiers Estimate
Laryngeal Neoplasms / pathology*
Larynx / pathology
Middle Aged
Mouth Mucosa / pathology
Neoplasm Invasiveness
Neoplasm Staging
Oropharyngeal Neoplasms / pathology*
Precancerous Conditions / pathology*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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