| 13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma: Initial Report. | |
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MedLine Citation:
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PMID: 21975388 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : Relatively high Tl-201 uptakes have been reported in all types of meningiomas, and it have been proposed that TlCl SPECT could predict histologic types of meningiomas and differentiate the benign and aggressive meningiomas. Similar to Tl-201, N-NH4 is an analog of K and could substitute K in some cases. The aim of this study was to evaluate the capacity of PET with N-NH3 to discriminate meningioma from healthy tissue, and compare with F-18 FDG. METHODS: : Eleven patients with the neuroradiologic diagnosis of meningiomas were studied with N-NH3, and 10 of them were performed with F-18 FDG PET within 3 days. Ten of them were histologically confirmed (6 grade I, 4 grade II), and another one was proved by radiologic (computed tomography and magnetic resonance imaging) and clinical investigation.The PET images were evaluated by semiquantitative analysis using tumor-to-white matter ratio (T/W). RESULTS: : N-NH3 uptake was obviously increased in all 11 meningiomas with a good contrast to the surrounding normal brain tissues. Conversely, F-18 FDG uptake was decreased in comparison with the contralateral side in all 7 patients with grade I meningiomas and moderately increased in the remaining patient with grade II meningioma. The T/W ratio of N-NH3 was higher than that of F-18 FDG (7.03 ± 1.62 vs. 1.44 ± 0.57, P < 0.005). T/W of N-NH3 uptake was not useful for differentiating benign (Grade I) from atypical (Grade II) meningiomas (P = 0.88), whereas the T/W ratio of F-18 FDG uptake was better than that of N-NH3 for differentiating benign from malignant meningiomas (P = 0.037). CONCLUSIONS: : These preliminary results suggest that N-NH3 has relatively greater uptake in meningiomas in comparison with F-18 FDG. Clinical applications of N-NH3 PET for grading and follow-up of meningiomas need to be assessed in further studies. |
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Authors:
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Zhang Xiangsong; Shi Xingchong; Yi Chang; Wang Xiaoyan; Chen Zhifeng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1003-6 Citation Subset: IM |
Affiliation:
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From the Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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