Document Detail


13C-octanoic acid breath test for gastric emptying measurement.
MedLine Citation:
PMID:  10656216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this multicentre study was to assess the accuracy and reproducibility of the 13C-octanoic acid breath test compared to scintigraphy for measurement of gastric emptying. METHODS: Sixty-nine healthy subjects (40 men, 29 women; mean age 30 years, range 21-61) were studied at least once by using the 13C-octanoic breath test. In 34 healthy subjects, gastric emptying was simultaneously measured by gastric scintigraphy, and the 13C-octanoic breath test was then repeated in 18 of these cases. Fifty-four patients (30 men, 24 women; mean age 46 years, range 13-74) with dyspeptic or reflux symptoms were studied according to the same procedure. RESULTS: The correlation between breath test and scintigraphic values was highly significant (r = 0.744, P<0.001). The concordance of results of scintigraphy and breath test (normal versus abnormal) and the reproducibility (Bland and Altman method) of the breath test were good (CVinter = 24%, CVintra = 15%). As compared to scintigraphy, breath test detected an abnormal gastric emptying with 67% sensitivity and 80% specificity (ROC analysis). CONCLUSION: These results confirm the value of breath test as an accurate measurement of gastric emptying. Its excellent reproducibility makes it a method of choice for pharmacological studies. However, at least when scintigraphy is considered the gold standard, breath test sensitivity may be insufficient for the detection of gastroparesis in an individual patient.
Authors:
B Delbende; F Perri; O Couturier; A Leodolter; P Mauger; B Bridgi; Y Bizais; S B des Varannes; A Andriulli; J P Galmiche
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  12     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-05-02     Completed Date:  2000-05-02     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology and Hepatology, CHU Hotel Dieu, Nantes, France (CRI INSERM 9508).
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Breath Tests
Carbon Isotopes
Case-Control Studies
Female
Gastric Emptying / physiology*
Gastroesophageal Reflux / physiopathology*,  radionuclide imaging*
Humans
Male
Middle Aged
Octanoic Acids / diagnostic use*,  metabolism
ROC Curve
Reproducibility of Results
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Octanoic Acids; 124-07-2/caprylic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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