Document Detail

(13)C hyperpolarization of a barbituric acid derivative via parahydrogen induced polarization.
MedLine Citation:
PMID:  20207180     Owner:  NLM     Status:  MEDLINE    
Significant (13)C NMR signal enhancement by a factor of 5000 of a barbituric acid derivative (5-methyl-5-propenyl-barbituric acid) via parahydrogen induced polarization is presented. This hyperpolarization is achieved by hydrogenating 5-methyl-5-propargyl-barbituric acid with 98% enriched para-H(2) under elevated temperature and pressure and transferring the initially created (1)H hyperpolarization with an INEPT-derived pulse sequence to (13)C. The polarization can be selectively transferred to different carbons in the barbituric acid derivative by applying different pulse delays in the INEPT pulse sequence. These results demonstrate the potential of using hyperpolarized barbituric acid derivatives as "active" contrast agents in MRI and visualizing their pharmacokinetics in vivo.
Meike Roth; Achim Koch; Petra Kindervater; Joachim Bargon; Hans Wolfgang Spiess; Kerstin Münnemann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-06
Journal Detail:
Title:  Journal of magnetic resonance (San Diego, Calif. : 1997)     Volume:  204     ISSN:  1096-0856     ISO Abbreviation:  J. Magn. Reson.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707935     Medline TA:  J Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Max-Planck-Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
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MeSH Terms
Barbiturates / chemistry*
Carbon Isotopes / chemistry
Contrast Media / analysis*,  chemical synthesis*
Hydrogen / chemistry*
Image Enhancement / methods*
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Reg. No./Substance:
0/Barbiturates; 0/Carbon Isotopes; 0/Contrast Media; 1333-74-0/Hydrogen; 67-52-7/barbituric acid

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