Document Detail

13C NMR spectroscopy: a convenient tool for detection of argininosuccinic aciduria.
MedLine Citation:
PMID:  11489385     Owner:  NLM     Status:  MEDLINE    
Proton decoupled high resolution 13C NMR spectra of argininosuccinic acid have been measured in a series of dilute water solutions of various acidity. These data have provided a basis for unequivocal determination of the presence of this metabolite in the investigated sample. The method additionally enables simultaneous rough estimation of the metabolite concentration. In order to check the practicability of the usage of this spectroscopy for diagnostic purposes, the spectra of several unprocessed urine samples have been recorded including three from patients with argininosuccinic aciduria. It has been concluded that 13C NMR spectroscopy can be a convenient method of recognising the above syndrome and probably many other inborn metabolic errors which manifest themselves with the excretion of the marker metabolite in amounts comparable to (or larger than) creatinine.
H Krawczyk; A Gryff-Keller; W Gradowska; M Duran; E Pronicka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  26     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-08-07     Completed Date:  2001-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  401-8     Citation Subset:  IM    
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664, Warsaw, Poland.
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MeSH Terms
Argininosuccinic Acid / urine*
Carbon Isotopes
Magnetic Resonance Spectroscopy
Reg. No./Substance:
0/Carbon Isotopes; 2387-71-5/Argininosuccinic Acid

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