| 13C MRS of occipital and frontal lobes at 3 T using a volume coil for stochastic proton decoupling. | |
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MedLine Citation:
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PMID: 20878974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previously, we devised a novel strategy for in vivo 13C MRS using [2-13C]glucose infusion and low-power proton decoupling, and proposed that this strategy could be used to acquire 13C MR spectra from the frontal lobe of the human brain. Here, we demonstrate, for the first time, in vivo 13C MRS of human frontal lobe acquired at 3 T. Because the primary metabolites of [2-13C]glucose can be decoupled using very-low-radiofrequency power, we used a volume coil for proton decoupling in this study. The homogeneous B(1) field of the volume coil was found to significantly enhance the decoupling efficiency of the stochastic decoupling sequence. Detailed specific absorption rates inside the human head were analyzed using the finite difference time domain method to ensure experimental safety. In vivo 13C spectra from the occipital and frontal lobes of the human brain were obtained. At a decoupling power of 30 W (time-averaged power, 2.45 W), the spectra from the occipital lobe showed well-resolved spectral resolution and excellent signal-to-noise ratio. Although frontal lobe 13C spectra were affected by local B(0) field inhomogeneity, we demonstrated that the spectral quality could be improved using post-acquisition data processing. In particular, we showed that the frontal lobe glutamine C5 at 178.5 ppm and aspartate C4 at 178.3 ppm could be spectrally resolved with effective proton decoupling and B(0) field correction. Because of its large spatial coverage, volume coil decoupling provides the potential to acquire 13C MRS from more than one brain region simultaneously. |
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Authors:
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Shizhe Li; Yan Zhang; Shumin Wang; Maria Ferraris Araneta; Christopher S Johnson; Yun Xiang; Robert B Innis; Jun Shen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: NMR in biomedicine Volume: 23 ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2011-01-06 Revised Date: 2011-08-29 |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 977-85 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Isotopes
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metabolism* Frontal Lobe* / anatomy & histology, metabolism Glucose / chemistry, metabolism Humans Magnetic Resonance Spectroscopy* / instrumentation, methods Models, Anatomic Occipital Lobe* / anatomy & histology, metabolism Protons* Reproducibility of Results Stochastic Processes |
| Grant Support | |
ID/Acronym/Agency:
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ZIA MH002795-09/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Protons; 50-99-7/Glucose |
| Comments/Corrections | |
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