| 131I in blood samples: a danger for professionals? A problem for immunoassays? | |
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MedLine Citation:
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PMID: 16145225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our objective was to investigate the safety of radioactive blood samples from patients receiving 131I and whether the radioactivity affects the validity of assays. METHODS: First, the activity of samples from patients given 131I was measured by 3 methods and compared with the upper threshold. Then, pilot sera were spiked with 131I, and possible interference was investigated using 2 immunoradiometric assays. RESULTS: The activity of 13 of the 15 samples was below the European limit; the other 2 samples were from patients with reduced renal clearance rates. No differences in thyroglobulin level or thyroid-stimulating hormone level were found between sera that were spiked with 131I and sera that were not. CONCLUSION: These blood samples are safe because they contain negligible activity, and the use of radioimmunoassays or immunoradiometric assays on them produces reliable results. |
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Authors:
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Julie Vialard-Miguel; Agnès Georges; Joaquim Mazère; Dominique Ducassou; Jean-Benoît Corcuff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine technology Volume: 33 ISSN: 0091-4916 ISO Abbreviation: J Nucl Med Technol Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-07 Completed Date: 2006-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0430303 Medline TA: J Nucl Med Technol Country: United States |
Other Details:
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Languages: eng Pagination: 172-4 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Department, University Hospital of Bordeaux and University Bordeaux 2, Bordeaux, France. julie.miguel@chu-bordeaux.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts* Europe Health Personnel* Hematologic Tests Iodine Radioisotopes / blood*, therapeutic use Occupational Exposure / analysis* Radiation Dosage Radiation Injuries / prevention & control Radiation Protection / methods Radioimmunoassay / methods* Radiometry / methods* Risk Assessment / methods* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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