Document Detail


A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration.
MedLine Citation:
PMID:  15953846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects; especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions; however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.
Authors:
Yuri Sano; Hiroshi Satoh; Momoko Chiba; Atsuko Shinohara; Masahide Okamoto; Koji Serizawa; Hiroshi Nakashima; Kazuyuki Omae
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of occupational health     Volume:  47     ISSN:  1341-9145     ISO Abbreviation:  J Occup Health     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-14     Completed Date:  2005-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616320     Medline TA:  J Occup Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  IM    
Affiliation:
Department of Preventative Medicine and Public Health, School of Medicine, Keio University, Japan. sanoyuri@sc.itc.keio.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Bismuth / administration & dosage,  analysis,  toxicity*
Lung / chemistry
Male
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
7440-69-9/Bismuth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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