Document Detail

A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration.
MedLine Citation:
PMID:  15953846     Owner:  NLM     Status:  MEDLINE    
Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects; especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions; however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.
Yuri Sano; Hiroshi Satoh; Momoko Chiba; Atsuko Shinohara; Masahide Okamoto; Koji Serizawa; Hiroshi Nakashima; Kazuyuki Omae
Related Documents :
18364406 - Efficacy of add-on topiramate therapy in psychiatric patients with weight gain.
8212006 - Quantitation of an epithelial s-phase response in the rat forestomach and glandular sto...
24504936 - The chronic toxicity of sodium bicarbonate, a major component of coal bed natural gas p...
23229376 - Influence of exposure and toxicokinetics on measures of aquatic toxicity for organic co...
10356766 - The life cycle of amblyomma neumanni ribaga, 1902 (acari: ixodidae) in the laboratory.
293686 - Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of occupational health     Volume:  47     ISSN:  1341-9145     ISO Abbreviation:  J Occup Health     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-14     Completed Date:  2005-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616320     Medline TA:  J Occup Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  IM    
Department of Preventative Medicine and Public Health, School of Medicine, Keio University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Bismuth / administration & dosage,  analysis,  toxicity*
Lung / chemistry
Rats, Sprague-Dawley
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Secular trends and geographical variations in the dietary intake of polybrominated diphenyl ethers (...
Next Document:  Thirteen-week inhalation toxicity of p-dichlorobenzene in mice and rats.