Document Detail


13-week inhalation toxicity study and fertility assessment in rats exposed to atmospheres containing adiponitrile.
MedLine Citation:
PMID:  2366257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adiponitrile is an aliphatic dinitrile that is used as an intermediate in the synthesis of hexamethylenediamine. In order to asses potential health effects associated with industrial exposure, rats were exposed 6 h/d, 5 d/wk for 4 or 13 wk to atmospheres containing a range of adiponitrile concentrations and observed for signs of toxicity. A fertility assessment was also included as a component of the 13-wk study. Mortality and reduced weight gain were observed within 1 wk only in rats exposed to 493 mg/m3. Evidence of slight anemia was present in rats exposed to 99 mg/m3 and above. There was no histopathological evidence of organ toxicity in about 30 tissues from both sexes exposed up to 99 mg/m3, the highest concentration tested, for 13 wk. In addition, fertility, as monitored by reproductive performance and litter parameters, was normal in both males and females similarly exposed.
Authors:
R D Short; W V Roloff; L D Kier; W E Ribelin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  30     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-16     Completed Date:  1990-08-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-207     Citation Subset:  IM    
Affiliation:
Department of Medicine and Health Sciences, Monsanto Company, St. Louis, MO 63167.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Female
Fertility / drug effects*
Male
Mortality
Nitriles / pharmacology,  toxicity*
Osmolar Concentration
Rats
Time Factors
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Nitriles; 111-69-3/adiponitrile

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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