| A 13-item score based on readily available risk factors predicted risk for 3-year mortality in heart failure. | |
| | |
MedLine Citation:
|
PMID: 23318335 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
QUESTION Does an integer score based on readily available risk factors predict risk for mortality in patients with heart failure (HF) and reduced or preserved left ventricular ejection fraction (EF)? METHODS DESIGN Collaborative study using individual patient data from 30 cohort studies (median follow-up 2.5 y) participating in the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) program. {Eligible studies included patients with HF, did not have EF criterion for patient recruitment, and reported all-cause mortality}*. Missing data (range 0% for age and sex to 51% for creatinine level) were imputed using a multiple imputation algorithm. SETTING International, including Argentina, Denmark, France, Israel, Italy, Japan, New Zealand, North America, Spain, Sweden, and the UK. PATIENTS 39 372 patients (mean age 67 y, 67% men) who had HF with reduced or preserved left ventricular EF. DESCRIPTION OF PREDICTION GUIDE Risk score (Web-based risk calculator www.heartfailurerisk.org) included 13 variables: age (score varied with EF), sex, smoking status, body mass index, duration of HF, systolic blood pressure (score varied with EF), EF, New York Heart Association (NYHA) class, serum creatinine level, diabetes, chronic obstructive pulmonary disease, use of β-blockers, and use of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. Maximum score is 57 points, and observed score range was 0 to 52 points. OUTCOME All-cause mortality. MAIN RESULTS 40% of patients died. Patients with higher risk scores had increased predicted and observed mortality at 3 years (Table). CONCLUSION A 13-item integer score based on readily available risk factors predicted risk for 3-year mortality in patients with heart failure and reduced or preserved ejection fraction.Predicted and observed risk for mortality by risk group in patients with heart failure†Risk group‡Number of patientsPredicted mortality at 3 y§Observed mortality at 3 y (95% CI)§1808311%8.8% (8.2 to 9.6)2716619%18% (17 to 19)3828328%27% (26 to 28)4720639%43% (41 to 44)5498053%55% (53 to 57)6365471%72% (70 to 73)†CI defined in Glossary.‡Risk groups are based on the first 4 quintiles (groups 1 to 4) and top 2 deciles (groups 5 and 6) of integer scores averaged across 25 imputed data sets; data sets were created using multiple imputation algorithms for missing data.§Data provided by author. |
| | |
Authors:
|
Saurav Chatterjee |
Related Documents
:
|
23415355 - Gestational diabetes mellitus among women born in south east asia: a review of the evid... 22524595 - The association between chronic exposure to traffic-related air pollution and ischemic ... 23444395 - Novel genetic markers improve measures of atrial fibrillation risk prediction. 23067045 - Self-reported hearing difficulties, main income sources, and socio-economic status; a c... 9074145 - Retained tubocornual endometrium and the tuma procedure 1923725 - Heredity and dysmorphic syndromes in congenital limb deficiencies. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Annals of internal medicine Volume: 158 ISSN: 1539-3704 ISO Abbreviation: Ann. Intern. Med. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: United States |
Other Details:
|
Languages: eng Pagination: JC13 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Review: Interventions for patient transition from hospital to primary care may improve outcomes.
Next Document: Review: General health checks in adults do not reduce all-cause, cardiovascular, or cancer mortality...