| 1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase. | |
| | |
MedLine Citation:
|
PMID: 22386717 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dihydrodipicolinate synthase is a key enzyme in the lysine biosynthesis pathway that catalyzes the condensation of pyruvate and aspartate semi-aldehyde. A series of phenolic ketoacid derivatives that mimic the proposed enzymatic intermediate were designed as potential inhibitors of this enzyme and were synthesized from simple precursors. The ketoacid derivatives were shown to act as slow and slow-tight binding inhibitors. Mass spectrometric experiments provided further evidence to support the proposed model of inhibition, demonstrating either an encounter complex or a condensation product for the slow and slow-tight binding inhibitors, respectively. |
| | |
Authors:
|
Berin A Boughton; Lilian Hor; Juliet A Gerrard; Craig A Hutton |
Related Documents
:
|
9182577 - Effects of mutating specific residues present near the amino terminus of 2'-5'-oligoade... 20933507 - Over-expression of coq10 in saccharomyces cerevisiae inhibits mitochondrial respiration. 10336637 - Changing the efficiency and specificity of the esterase activity of human carbonic anhy... 22369147 - 3-aminopiperidine-based peptide analogues as the first selective noncovalent inhibitors... 11724797 - Cysteine-directed cross-linking to subunit b suggests that subunit e forms part of the ... 16126167 - Structural and functional differences between cyclooxygenases: fatty acid oxygenases wi... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-10 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry Volume: - ISSN: 1464-3391 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
School of Chemistry, The University of Melbourne, VIC 3010, Australia; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: l-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia.
Next Document: Use of computed tomography and silicon endocasts to identify pulmonary veins with echocardiography.