| 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates. | |
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MedLine Citation:
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PMID: 22198282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ocular hypertension is the greatest known risk factor for glaucoma that affects an estimated 70 million people worldwide. Lowering intraocular pressure (IOP) remains the mainstay of therapy in the management of glaucoma. By means of microarray analysis, we have discovered that 1α,25-dihydroxyvitamin D(3) (1α,25-(OH)(2)D(3)) regulates genes that are known to be involved in the determination of intraocular pressure (IOP). Topical administration of 1α,25-(OH)(2)D(3) or its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), markedly reduces IOP in non-human primates. The reduction in IOP is not the result of reduced aqueous humor formation, while a 35% increase in aqueous humor drainage by 1α,25-(OH)(2)D(3) was found but this increase did not achieve significance. Nevertheless, our results suggest that 1α,25-(OH)(2)D(3), or an analog thereof, may present a new approach to the treatment of glaucoma. |
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Authors:
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Galina D Kutuzova; B'ann T Gabelt; Julie A Kiland; Elizabeth A Hennes-Beann; Paul L Kaufman; Hector F DeLuca |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-12-16 |
Journal Detail:
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Title: Archives of biochemistry and biophysics Volume: 518 ISSN: 1096-0384 ISO Abbreviation: Arch. Biochem. Biophys. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-23 Completed Date: 2012-03-05 Revised Date: 2012-04-25 |
Medline Journal Info:
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Nlm Unique ID: 0372430 Medline TA: Arch Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 53-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706-1544, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Aqueous Humor / drug effects, metabolism Blood Pressure / drug effects Calcitriol / administration & dosage, analogs & derivatives*, chemistry, pharmacology* Calcium / blood Eye / blood supply, drug effects, metabolism Female Intraocular Pressure / drug effects* Macaca fascicularis Male Mice Rats Transcriptome / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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P30 EY016665/EY/NEI NIH HHS; P30 EY016665/EY/NEI NIH HHS; P30 EY016665-01/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3; 32222-06-3/Calcitriol; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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