Document Detail

1,25-Dihydroxyvitamin D3 inhibits thromboxane release from activated macrophages.
MedLine Citation:
PMID:  1475528     Owner:  NLM     Status:  MEDLINE    
1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) in concentrations from 0.1 to 10 nM suppressed immunoreactive thromboxane B2 (iTXB2) release from Propionibacterium acnes (P. acnes)-elicited liver adherent cells stimulated with lipopolysaccharide (LPS, 1 microgram/ml). These suppressive effects of 1,25-(OH)2D3 were also observed in oyster glycogen-elicited peritoneal macrophages. On the contrary, it did not inhibit iTXB2 release from both resident Kupffer cells and peritoneal macrophages stimulated with the same concentration of LPS. Furthermore, 1,24(R)-dihydroxyvitamin D3 (1,24(R)-(OH)2D3), a vitamin D3 analogue, also inhibited iTXB2 release from liver adherent cells, but, another synthesized vitamin D3 analogue, 1 alpha-hydroxyvitamin D3 (1 alpha-OH-D3) tended to decrease iTXB2 release only at higher concentrations. These results suggest that active vitamin D3 analogues inhibit iTXB2 release from activated macrophages.
H Horiuchi; I Nagata; K Takahashi; M Tsuchimoto; K Komoriya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  78     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-03     Completed Date:  1993-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-43     Citation Subset:  IM    
Teijin Institute for Bio-Medical Research, Tokyo, Japan.
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MeSH Terms
Calcitriol / pharmacology*
Dihydroxycholecalciferols / pharmacology
Endotoxins / administration & dosage
Kupffer Cells / drug effects
Liver / drug effects
Macrophage Activation
Macrophages / metabolism*
Mice, Inbred BALB C
Peritoneal Cavity
Propionibacterium acnes
Thromboxane B2 / antagonists & inhibitors*,  metabolism
Reg. No./Substance:
0/Dihydroxycholecalciferols; 0/Endotoxins; 0/Lipopolysaccharides; 32222-06-3/Calcitriol; 54397-85-2/Thromboxane B2; 60965-80-2/1 alpha,24-dihydroxyvitamin D3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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