Document Detail

1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells.
MedLine Citation:
PMID:  1995862     Owner:  NLM     Status:  MEDLINE    
Intraluminal injection of female rats at Day 5 of pseudopregnancy with 10-500 ng 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) significantly increased the uterine weight and induced decidual reaction. This effect was observed as early as the 3rd day after 1,25-(OH)2D3 injection. It was detectable only in the injected left horn and not in the non-injected right horn. A 500 ng dose of 25-(OH)D3 had no such effect. The present in-vivo results suggest that 1,25-(OH)2D3 may play a physiological role in endometrial cell differentiation into decidual cells, a crucial step in the process of blastocyst implantation.
A Halhali; G M Acker; M Garabédian
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  91     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-03-26     Completed Date:  1991-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
CNRS URA 583-Université Paris V, Hôpital des Enfants Malades, Paris, France.
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MeSH Terms
Calcifediol / pharmacology
Calcitriol / pharmacology*
Decidua / growth & development
Endometrium / drug effects*
Organ Size / drug effects
Rats, Inbred Strains
Uterus / anatomy & histology
Reg. No./Substance:
19356-17-3/Calcifediol; 32222-06-3/Calcitriol

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