Document Detail

1,25-Dihydroxy vitamin D and coronary microvascular function.
MedLine Citation:
PMID:  23151909     Owner:  NLM     Status:  Publisher    
PURPOSE: The active form of vitamin D (1,25(OH)(2)D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess cardiovascular risk in patients with disorders of mineral metabolism. METHODS: As a clinical model of the wide variability in 1,25(OH)(2)D bioavailability, we studied 23 patients (62 ± 8 years) with suspected primary hyperparathyroidism referred for myocardial perfusion imaging because of atypical chest pain and at least one cardiovascular risk factor. Dipyridamole and baseline myocardial blood flow indexes were assessed on G-SPECT imaging of (99m)Tc-tetrofosmin, with normalization of the myocardial count rate to the corresponding first-transit counts in the pulmonary artery. Coronary flow reserve (CFR) was defined as the ratio between dipyridamole and baseline myocardial blood flow indexes. In all patients, parathyroid hormone, 25-hydroxy vitamin D (25(OH)D) and 1,25(OH)(2)D serum levels were determined. RESULTS: Primary hyperparathyroidism was eventually diagnosed in 15 of the 23 patients. The mean 25(OH)D concentration was relatively low (21 ± 10 ng/mL) while the concentrations of 1,25(OH)(2)D varied widely but within the normal range (mean 95 ± 61 pmol/L). No patient showed reversible perfusion defects on G-SPECT. CFR was not correlated with either the serum concentration of 25(OH)D nor that of parathyroid hormone, but was strictly correlated with the serum level of 1,25(OH)(2)D (R = 0.8, p < 0.01). Moreover, patients with a 1,25(OH)(2)D concentration below the median value (86 pmol/L) had markedly lower CFR than the other patients (1.48 ± 0.40 vs. 2.51 ± 0.63, respectively; p < 0.001). CONCLUSION: Bioavailable 1,25(OH)(2)D modulates coronary microvascular function. This effect might contribute to the high cardiovascular risk of conditions characterized by chronic reduction in bioavailability of this hormone.
Selene Capitanio; Gianmario Sambuceti; Massimo Giusti; Silvia Morbelli; Giovanni Murialdo; Giacomo Garibotto; Lara Vera; Pietro Ameri; Barbara Repetto; Mehrdad Naseri; Irene Bossert; Maria Teresa Verardi; Michela Massollo; Cecilia Marini
Related Documents :
23197169 - Coronary tomography for predicting adverse events in patients with suspected coronary d...
24408069 - The relationship between gensini score and st-segment resolution in patients with acute...
24473509 - Predictors of in-hospital mortality in patients with st-segment elevation myocardial in...
24481089 - The degree of left atrial structural remodeling impacts left ventricular ejection fract...
23377899 - Prognostic evaluation of catalytic iron in patients with acute coronary syndromes.
21856909 - Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning and...
2240249 - Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion.
21211689 - Noninvasive identification of ventricular tachycardia-related conducting channels using...
24107999 - An observational study of extracorporeal cpr for in-hospital cardiac arrest secondary t...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  -     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Nuclear Medicine, University of Genoa, Genoa, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of t...
Next Document:  (11)C-Choline PET/CT in patients with hormone-resistant prostate cancer showing biochemical relapse ...