Document Detail

1,2,4-trichlorobenzene marine risk assessment with special emphasis on the Osparcom region North Sea.
MedLine Citation:
PMID:  16271379     Owner:  NLM     Status:  MEDLINE    
A risk assessment on 1,2,4-trichlorobenzene was carried out specifically for the marine environment according to the methodology laid down in the EU Risk Assessment Regulation 1488/94 and the Guidance Documents of the EU Existing Substances Regulation 793/93. The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by comparing the predicted environmental concentration (PEC) with the predicted no-effect concentrations (PNEC) for the marine aquatic environment. A PNECwater) value of 0.3 microg/l and a PNECsed value of 38 microg/kgdw were derived from the results of toxicological studies in organisms representing three trophic levels, i.e. aquatic plants, invertebrates and fish. Based on monitoring data two situations are distinguished: a typical case and a worst case with a PECwater of <0.047 and 0.1 microg/l, respectively, and a PECsed of 40 and 90 microg/kgdw, respectively. The calculated PEC/PNEC ratios were 0.16 and 0.3 for water and 1 and 2.4 for sediment, respectively. It was concluded that no risks are expected for aquatic organisms. Based on the combination of worst-case assumptions risks to benthic organisms could not be fully excluded, but since all open uses of 1,2,4-trichlorobenzene will be ended following the EU risk assessment outcome of 2001 any potential risk is expected to be reduced accordingly. 1,2,4-trichlorobenzene is not considered toxic according to the EU criteria and the available data on persistence of 1,2,4-trichlorobenzene indicate a half-life in water of a few days and a significant biodegradation potential. The bioaccumulation potential is low to moderate with most BCF ratios for fish ranging from 600 to 1400 and one highest of 2020. Based on an extensive evaluation of persistence, biodegradation and bioaccumulation data it is concluded that 1,2,4-trichlorobenzene is not a PBT, since it does not fulfill any of the EU criteria. Biomagnification in the food chain is not expected due to the relatively high elimination rate constants.
D van Wijk; E Cohet; A Gard; N Caspers; C van Ginkel; R Thompson; C de Rooij; V Garny; A Lecloux
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Publication Detail:
Type:  Journal Article     Date:  2005-11-03
Journal Detail:
Title:  Chemosphere     Volume:  62     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1294-310     Citation Subset:  IM    
Euro Chlor, Avenue van Nieuwenhuyse 4, Box 2, 1160 Brussels, Belgium.
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MeSH Terms
Biodegradation, Environmental
Biological Availability
Chlorobenzenes / analysis,  pharmacokinetics,  toxicity*
Dose-Response Relationship, Drug
Environmental Monitoring
Fresh Water / analysis
Marine Biology
North Sea
Risk Assessment
Water Pollutants, Chemical / analysis,  pharmacokinetics,  toxicity*
Reg. No./Substance:
0/Chlorobenzenes; 0/Water Pollutants, Chemical; 120-82-1/1,2,4-trichlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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