Document Detail


123I-MIBG uptake in the neck and shoulders of a neuroblastoma patient: damage to sympathetic innervation blocks uptake in brown adipose tissue.
MedLine Citation:
PMID:  15205842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uptake of (123)I-MIBG in the neck and shoulders has recently been shown to be caused by uptake in brown adipose tissue. Unilateral absence of (123)I-MIBG uptake in brown adipose tissue ipsilateral to the clinical findings of a post-surgical Horner's syndrome suggests that, in humans, as in the animal model, uptake in brown adipose tissue is mediated by the sympathetic nervous system. This case further elucidates the mechanism of radiopharmaceutical uptake in brown adipose tissue and also suggests possible models for future studies of the physiology and pharmacology of brown adipose tissue.
Authors:
Michael J Gelfand
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2004-03-03
Journal Detail:
Title:  Pediatric radiology     Volume:  34     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-18     Completed Date:  2005-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  577-9     Citation Subset:  IM    
Affiliation:
Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio, USA. michael.gelfand@cchmc.org
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MeSH Terms
Descriptor/Qualifier:
3-Iodobenzylguanidine / pharmacokinetics*
Adipose Tissue, Brown / metabolism,  radionuclide imaging*
Child, Preschool
Female
Humans
Neck
Neuroblastoma / metabolism,  radionuclide imaging*
Radiopharmaceuticals / pharmacokinetics*
Shoulder
Sympathetic Nervous System / injuries*
Tomography, Emission-Computed, Single-Photon*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 77679-27-7/3-Iodobenzylguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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