Document Detail


I-123 MIBG and serial radionuclide angiocardiography in doxorubicin-related cardiotoxicity.
MedLine Citation:
PMID:  1611784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In six patients with doxorubicin-related cardiotoxicity, the severity of decrease in left ventricle ejection fraction (LVEF) was associated with faster myocardial I-123 MIBG washout rates. In four patients with severely decreased LVEF (range 19% to 28%), the 4-hour washout rate varied from 43% to 56%. In two patients with moderate cardiotoxicity (LVEF 42% and 43%), the washout rates were 37% and 35%, respectively. In contrast, in another patient thought to have initial left ventricular dysfunction (LVEF dropped from 66% to 54%), the myocardial I-123 MIBG retention rate was not reduced (6% washout). Subsequent continuation of chemotherapy in this patient was without complication. Reduced I-123 MIBG uptake in the left ventricle generally correlated with areas with abnormal Fourier amplitude values, but in one of the patients with moderate cardiotoxicity, the I-123 MIBG uptake was not reduced in a region with loss of amplitude, indicating dysfunction but probably no myocardial denervation. Analysis of the regional myocardial retention in patients with cardiotoxicity showed no significant difference in the I-123 MIBG washout rates of both segments with or without loss of amplitude. These data suggest that in spite of a localized loss of ventricular function demonstrated by radionuclide angiocardiography, doxorubicin-related cardiotoxicity appears to be based on a global process of myocardial adrenergic derangement.
Authors:
R A Valdés Olmos; W W ten Bokkel Huinink; J C Greve; C A Hoefnagel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  17     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam.
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MeSH Terms
Descriptor/Qualifier:
3-Iodobenzylguanidine
Adult
Doxorubicin / adverse effects*
Female
Gated Blood-Pool Imaging*
Heart / drug effects*,  radionuclide imaging
Humans
Iodine Radioisotopes / diagnostic use
Iodobenzenes / diagnostic use*
Male
Middle Aged
Neoplasms / drug therapy*
Stroke Volume / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Iodobenzenes; 23214-92-8/Doxorubicin; 77679-27-7/3-Iodobenzylguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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