| I-123 MIBG and serial radionuclide angiocardiography in doxorubicin-related cardiotoxicity. | |
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MedLine Citation:
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PMID: 1611784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In six patients with doxorubicin-related cardiotoxicity, the severity of decrease in left ventricle ejection fraction (LVEF) was associated with faster myocardial I-123 MIBG washout rates. In four patients with severely decreased LVEF (range 19% to 28%), the 4-hour washout rate varied from 43% to 56%. In two patients with moderate cardiotoxicity (LVEF 42% and 43%), the washout rates were 37% and 35%, respectively. In contrast, in another patient thought to have initial left ventricular dysfunction (LVEF dropped from 66% to 54%), the myocardial I-123 MIBG retention rate was not reduced (6% washout). Subsequent continuation of chemotherapy in this patient was without complication. Reduced I-123 MIBG uptake in the left ventricle generally correlated with areas with abnormal Fourier amplitude values, but in one of the patients with moderate cardiotoxicity, the I-123 MIBG uptake was not reduced in a region with loss of amplitude, indicating dysfunction but probably no myocardial denervation. Analysis of the regional myocardial retention in patients with cardiotoxicity showed no significant difference in the I-123 MIBG washout rates of both segments with or without loss of amplitude. These data suggest that in spite of a localized loss of ventricular function demonstrated by radionuclide angiocardiography, doxorubicin-related cardiotoxicity appears to be based on a global process of myocardial adrenergic derangement. |
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Authors:
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R A Valdés Olmos; W W ten Bokkel Huinink; J C Greve; C A Hoefnagel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 17 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-07-30 Completed Date: 1992-07-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-7 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine Adult Doxorubicin / adverse effects* Female Gated Blood-Pool Imaging* Heart / drug effects*, radionuclide imaging Humans Iodine Radioisotopes / diagnostic use Iodobenzenes / diagnostic use* Male Middle Aged Neoplasms / drug therapy* Stroke Volume / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Iodobenzenes; 23214-92-8/Doxorubicin; 77679-27-7/3-Iodobenzylguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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