Document Detail

A 12-year retrospective study of non-burn skin loss (burn-like syndromes) at a tertiary burns unit in a developing country.
MedLine Citation:
PMID:  18226456     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A retrospective study of the presentation, etiology, and prognosis of non-burn epidermal loss managed at the Lagos University Teaching Hospital Nigeria over a 12-year period. MATERIALS AND METHODS: Admission records of patients managed for non-burn skin loss were retrieved from the medical records. Demographic details of the patients, the initial diagnosis, final diagnosis, treatment and outcome of treatment was noted. RESULTS: A total of 23 patients were identified, 17 (74%) had idiosyncratic drug reactions. Of this 17, 6 (26%) had Steven Johnson Syndrome, 6 (26%) had Steven Johnson Syndrome/toxic epidermal necrolysis while 5 (22%) presented with toxic epidermal necrolysis. Three of the five patients with toxic epidermal necrolysis died. The age range of patients with idiosyncratic adverse drug reactions was 2-28 years, mean, 10.18+/-1.44 years and male to female ratio of 1:1.83. The body surface area involved ranged from 8 to 78%; mean 26.65+/-6.08%. The agents suspected for the reactions were Co-trimoxazole (41.2%) and combination of Co-trimoxazole, and Fansidar (17.6%). Other conditions seen were two (9%) Staphylococcal Scalded Skin Syndrome, three (13%) had Necrotizing Faciitis, one of whom was HIV positive and died. One (4%) patient presented with pemphigus vulgaris. The presentation and management of the patients was discussed.
A O Ugburo; E O Temiye; C A Ilombu
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Publication Detail:
Type:  Journal Article     Date:  2008-01-15
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  34     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  637-43     Citation Subset:  IM    
Department of Surgery, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Lagos, Nigeria.
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MeSH Terms
Anti-Infective Agents / adverse effects
Bandages / adverse effects
Burn Units
Child, Preschool
Developing Countries*
Drug Combinations
Epidermal Necrolysis, Toxic / etiology*,  pathology,  therapy
Pyrimethamine / adverse effects
Retrospective Studies
Staphylococcal Scalded Skin Syndrome / etiology,  pathology
Stevens-Johnson Syndrome / etiology*,  pathology,  therapy
Sulfadoxine / adverse effects
Trimethoprim-Sulfamethoxazole Combination / adverse effects
Reg. No./Substance:
0/Anti-Infective Agents; 0/Drug Combinations; 2447-57-6/Sulfadoxine; 37338-39-9/sulfadoxine-pyrimethamine; 58-14-0/Pyrimethamine; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

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