| A 12-year retrospective study of non-burn skin loss (burn-like syndromes) at a tertiary burns unit in a developing country. | |
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MedLine Citation:
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PMID: 18226456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A retrospective study of the presentation, etiology, and prognosis of non-burn epidermal loss managed at the Lagos University Teaching Hospital Nigeria over a 12-year period. MATERIALS AND METHODS: Admission records of patients managed for non-burn skin loss were retrieved from the medical records. Demographic details of the patients, the initial diagnosis, final diagnosis, treatment and outcome of treatment was noted. RESULTS: A total of 23 patients were identified, 17 (74%) had idiosyncratic drug reactions. Of this 17, 6 (26%) had Steven Johnson Syndrome, 6 (26%) had Steven Johnson Syndrome/toxic epidermal necrolysis while 5 (22%) presented with toxic epidermal necrolysis. Three of the five patients with toxic epidermal necrolysis died. The age range of patients with idiosyncratic adverse drug reactions was 2-28 years, mean, 10.18+/-1.44 years and male to female ratio of 1:1.83. The body surface area involved ranged from 8 to 78%; mean 26.65+/-6.08%. The agents suspected for the reactions were Co-trimoxazole (41.2%) and combination of Co-trimoxazole, and Fansidar (17.6%). Other conditions seen were two (9%) Staphylococcal Scalded Skin Syndrome, three (13%) had Necrotizing Faciitis, one of whom was HIV positive and died. One (4%) patient presented with pemphigus vulgaris. The presentation and management of the patients was discussed. |
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Authors:
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A O Ugburo; E O Temiye; C A Ilombu |
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Publication Detail:
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Type: Journal Article Date: 2008-01-15 |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 34 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-06-10 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: England |
Other Details:
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Languages: eng Pagination: 637-43 Citation Subset: IM |
Affiliation:
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Department of Surgery, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Lagos, Nigeria. andyugburo@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Infective Agents / adverse effects Bandages / adverse effects Burn Units Child Child, Preschool Developing Countries* Drug Combinations Epidermal Necrolysis, Toxic / etiology*, pathology, therapy Female Humans Male Nigeria Prognosis Pyrimethamine / adverse effects Retrospective Studies Staphylococcal Scalded Skin Syndrome / etiology, pathology Stevens-Johnson Syndrome / etiology*, pathology, therapy Sulfadoxine / adverse effects Trimethoprim-Sulfamethoxazole Combination / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Drug Combinations; 2447-57-6/Sulfadoxine; 37338-39-9/sulfadoxine-pyrimethamine; 58-14-0/Pyrimethamine; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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