Document Detail

The 1,2-benzenedithiole-based cyclocondensation assay: a valuable tool for the measurement of chemopreventive isothiocyanates.
MedLine Citation:
PMID:  22452732     Owner:  NLM     Status:  MEDLINE    
Many naturally occurring isothiocyanates (ITCs) show highly promising chemopreventive activities. Humans are commonly exposed to these compounds through the consumption of cruciferous vegetables which are the main source of dietary ITCs. Dietary ITCs may play an important role in cancer prevention and in the well-recognized cancer preventive activities of cruciferous vegetables. A generic analytical method, namely the 1,2-benzenedithiol-based cyclocondensation assay, was previously developed for quantitation of ITCs and their in vivo metabolites. This method has been widely used and has contributed greatly to research on chemoprevention by ITCs. In this article, the discovery and development of the cyclocondensation assay are recapitulated, and its sensitivity and specificity as well as its advantages and limitations are scrutinized. Moreover, detailed discussion is also provided to show how this assay has been used to advance our understanding of the cancer chemopreventive potential and the mechanism of action of ITCs.
Yuesheng Zhang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Critical reviews in food science and nutrition     Volume:  52     ISSN:  1549-7852     ISO Abbreviation:  Crit Rev Food Sci Nutr     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-28     Completed Date:  2012-07-26     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8914818     Medline TA:  Crit Rev Food Sci Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  525-32     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents, Phytogenic / chemistry*,  pharmacology*
Food Analysis / methods*
Isothiocyanates / chemistry*,  pharmacology*
Sensitivity and Specificity
Sulfhydryl Compounds / chemistry*
Grant Support
R01 CA124627/CA/NCI NIH HHS; R01 CA124627-02/CA/NCI NIH HHS; R01 CA124627-03/CA/NCI NIH HHS; R01CA124627/CA/NCI NIH HHS
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Isothiocyanates; 0/Sulfhydryl Compounds; 17534-15-5/1,2-benzenedithiol

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