| A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents. | |
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MedLine Citation:
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PMID: 19696755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rise in obesity-related morbidity in children and adolescents requires urgent prevention and treatment strategies. Currently, only limited data are available on the effects of exercise programs on insulin resistance, and visceral, hepatic, and intramyocellular fat accumulation. We hypothesized that a 12-week controlled aerobic exercise program without weight loss reduces visceral, hepatic, and intramyocellular fat content and decreases insulin resistance in sedentary Hispanic adolescents. Twenty-nine postpubertal (Tanner stage IV and V), Hispanic adolescents, 15 obese (7 boys, 8 girls; 15.6 +/- 0.4 years; 33.7 +/- 1.1 kg/m(2); 38.3 +/- 1.5% body fat) and 14 lean (10 boys, 4 girls; 15.1 +/- 0.3 years; 20.6 +/- 0.8 kg/m(2); 18.9 +/- 1.5% body fat), completed a 12-week aerobic exercise program (4 x 30 min/week at > or =70% of peak oxygen consumption (VO(2)peak)). Measurements of cardiovascular fitness, visceral, hepatic, and intramyocellular fat content (magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS)), and insulin resistance were obtained at baseline and postexercise. In both groups, fitness increased (obese: 13 +/- 2%, lean: 16 +/- 4%; both P < 0.01). In obese participants, intramyocellular fat remained unchanged, whereas hepatic fat content decreased from 8.9 +/- 3.2 to 5.6 +/- 1.8%; P < 0.05 and visceral fat content from 54.7 +/- 6.0 to 49.6 +/- 5.5 cm(2); P < 0.05. Insulin resistance decreased indicated by decreased fasting insulin (21.8 +/- 2.7 to 18.2 +/- 2.4 microU/ml; P < 0.01) and homeostasis model assessment of insulin resistance (HOMA(IR)) (4.9 +/- 0.7 to 4.1 +/- 0.6; P < 0.01). The decrease in visceral fat correlated with the decrease in fasting insulin (R(2) = 0.40; P < 0.05). No significant changes were observed in any parameter in lean participants except a small increase in lean body mass (LBM). Thus, a controlled aerobic exercise program, without weight loss, reduced hepatic and visceral fat accumulation, and decreased insulin resistance in obese adolescents. |
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Authors:
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Gert-Jan van der Heijden; Zhiyue J Wang; Zili D Chu; Pieter J J Sauer; Morey W Haymond; Luisa M Rodriguez; Agneta L Sunehag |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-08-20 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-02-22 Revised Date: 2010-04-28 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 384-90 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adiposity / ethnology* Adolescent Adolescent Development* Body Mass Index Energy Intake Exercise Therapy* Exercise Tolerance Fatty Liver / ethnology, etiology, physiopathology, prevention & control* Female Heart Rate Hispanic Americans* / statistics & numerical data Humans Insulin Resistance / ethnology* Intra-Abdominal Fat / physiopathology Liver / physiopathology* Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Obesity / complications, ethnology, physiopathology, therapy* Oxygen Consumption Patient Compliance Sedentary Lifestyle / ethnology Time Factors Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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MO1-RR-00188-34/RR/NCRR NIH HHS; R01 HD044609/HD/NICHD NIH HHS |
| Comments/Corrections | |
Erratum In:
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Obesity (Silver Spring). 2010 May;18(5):1062 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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