| 11beta-Hydroxysteroid dehydrogenase type 2 activity is associated with left ventricular mass in essential hypertension. | |
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MedLine Citation:
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PMID: 15618035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Left ventricular mass (LVM) is under the control of aldosterone and angiotensin II in experimental hypertension, but the effect of aldosterone on LVM is controversial in essential hypertension (EH). Some EH patients show a mild impairment of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity without clinical features of the syndrome of apparent mineralocorticoid excess, where the incomplete cortisol-to-cortisone conversion leads to glucocorticoid-mediated mineralocorticoid effects. The mineralocorticoid receptor and 11beta-HSD2 are co-expressed in human heart. We investigated whether LVM may be regulated by glucocorticoids in EH patients. METHODS AND RESULTS: The ratio between 24 h urinary tetrahydro derivatives of cortisol and cortisone (THFs/THE), plasma renin activity, 24 h urinary aldosterone, blood pressure, and LVM indexed for height(2.7) (LVMh(2.7)) were analysed in 493 never-treated hypertensives and 98 normotensives. THFs/THE was associated with LVMh(2.7) in hypertensives and normotensives (r=0.32, P<0.001, and r=0.17, P=0.04, respectively) and persisted after adjusting for confounders (multiple regression analysis). Body mass index, sex, recumbent plasma renin activity, and THFs/THE accounted for 26.1% of LVMh(2.7) variation. Urinary aldosterone was not correlated with LVMh(2.7). CONCLUSION: We suggest that glucocorticoids may take part in the regulation of LVM in EH patients as a function of 11beta-HSD2 activity, and contribute to the target organ damage associated with essential hypertension. |
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Authors:
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Nicola Glorioso; Fabiana Filigheddu; Paolo Pinna Parpaglia; Aldo Soro; Chiara Troffa; Giuseppe Argiolas; Paolo Mulatero |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-15 |
Journal Detail:
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Title: European heart journal Volume: 26 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-16 Completed Date: 2005-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 498-504 Citation Subset: IM |
Affiliation:
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Hypertension and Cardiovascular Prevention Centre, ASL n.1-University of Sassari, Italy. glorioso@uniss.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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11-beta-Hydroxysteroid Dehydrogenase Type 2
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metabolism* Aldosterone / urine Blood Pressure / physiology Cohort Studies Cortodoxone / analogs & derivatives*, urine Echocardiography / methods Female Glucocorticoids / metabolism* Humans Hypertension / enzymology*, pathology, urine Hypertrophy, Left Ventricular / enzymology*, pathology, urine Male Middle Aged Renin / metabolism Tetrahydrocortisol / urine Tetrahydrocortisone / urine |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 152-58-9/Cortodoxone; 52-39-1/Aldosterone; 53-02-1/Tetrahydrocortisol; 53-05-4/Tetrahydrocortisone; 68-60-0/tetrahydro-11-deoxycortisol; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenase Type 2; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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