| [(11)C]Choline positron emission tomography/computed tomography for staging and restaging of patients with advanced prostate cancer. | |
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MedLine Citation:
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PMID: 18678354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: To evaluate [(11)C]Choline positron emission tomography (PET)/computed tomography (CT) for staging and restaging of patients with advanced prostate cancer and to compare the diagnostic performance of PET, CT and PET/CT. METHODS: Forty-five consecutive patients with advanced prostate cancer underwent [(11)C]Choline-PET/CT between 5/2004 and 2/2006. RESULTS: Overall, 295 lesions were detected: PET alone, 178 lesions; diagnostic CT, 221 lesions; PET/CT (low-dose CT), 272 lesions; PET/CT (diagnostic CT), 295 lesions. Two thirds of the lesions were located in the bone; one third in the prostate, lymph nodes, periprostatic tissue and soft tissue (lung, liver). The use of diagnostic CT did not result in a statistically significant difference with respect to lesion localization certainty and lesion characterization (P=.063, P=.063). PET-negative but PET/CT-positive lesions were mostly localized in the bone (78%, 91/117) as were PET-positive and CT-negative lesions (72%, 53/74). Of the latter, 91% (48/53) represented bone marrow and 9% (5/53) cortical involvement. CONCLUSIONS: Staging and restaging with [(11)C]Choline PET/CT in patients with advanced prostate cancer improve the assessment of local and regional recurrent as well as metastatic disease including skeletal manifestations. [(11)C]Choline PET/CT (with a low-dose CT) results in improved localization and lesion characterization. [(11)C]Choline PET/CT provides an added value for skeletal manifestations. [(11)C]Choline PET/CT changed disease management in 11 (24%) of 45 patients with advanced prostate cancer. |
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Authors:
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Murat Tuncel; Michael Souvatzoglou; Ken Herrmann; Jens Stollfuss; Tibor Schuster; Gregor Weirich; Hans-Jürgen Wester; Markus Schwaiger; Bernd J Krause |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 35 ISSN: 0969-8051 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-05 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 689-95 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Klinikum rechts der lsar, Technische Universität München, Munich, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Bone Neoplasms / diagnosis*, secondary* Carbon Radioisotopes / diagnostic use Choline / diagnostic use* Humans Male Middle Aged Neoplasm Metastasis Neoplasm Staging / methods Positron-Emission Tomography / methods* Prostatic Neoplasms / diagnosis* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Radiopharmaceuticals; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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