Document Detail

11C-methionine uptake in cerebrovascular disease: a comparison with 18F-fDG PET and 99mTc-HMPAO SPECT.
MedLine Citation:
PMID:  12126046     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. METHODS: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. RESULTS: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. CONCLUSIONS: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake.
Makoto Nakagawa; Yasuo Kuwabara; Masayuki Sasaki; Hirofumi Koga; Tao Chen; Ouichirou Kaneko; Kazutaka Hayashi; Takato Morioka; Kouji Masuda
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  16     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2003-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  IM    
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Cerebral Hemorrhage / metabolism*,  radionuclide imaging
Cerebral Infarction / metabolism*,  radionuclide imaging
Fluorodeoxyglucose F18 / diagnostic use,  pharmacokinetics*
Hematoma / metabolism*,  radionuclide imaging
Methionine / diagnostic use,  pharmacokinetics*
Middle Aged
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Retrospective Studies
Technetium Tc 99m Exametazime / diagnostic use,  pharmacokinetics*
Tissue Distribution
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime; 58576-49-1/carbon-11 methionine; 63-68-3/Methionine; 63503-12-8/Fluorodeoxyglucose F18

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