| 11C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression. | |
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MedLine Citation:
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PMID: 19837755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchymal microglia of the central nervous system. METHODS: Using a PET technique with (11)C-(R)-[1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinolinecarboxamide] ((11)C-PK11195), a PET ligand for peripheral type-benzodiazepine receptor, we evaluated the microglial activation in the rat brain after generation of unilateral cortical spreading depression, a stimulation used to bring up an experimental animal model of migraine. RESULTS: We found a significant increase in the brain uptake of (11)C-PK11195, which was completely displaceable by the excess amounts of unlabeled ligands, in the ipsilateral hemisphere of the spreading depression-generated rats. Moreover, the binding potential of (11)C-PK11195 in the spreading depression-generated rats was significantly higher than that in the sham-operated control rats. CONCLUSION: These results suggest that as an inflammatory reaction, microglial cells are activated in response to the nociceptive stimuli induced by cortical spreading depression in the rat brain. Therefore, the (11)C-PK11195 PET technique could have a potential for diagnostic and therapeutic monitoring of neurologic disorders related to neuroinflammation such as migraine. |
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Authors:
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Yilong Cui; Tadayuki Takashima; Misato Takashima-Hirano; Yasuhiro Wada; Miho Shukuri; Yasuhisa Tamura; Hisashi Doi; Hirotaka Onoe; Yosky Kataoka; Yasuyoshi Watanabe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-16 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 50 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1904-11 Citation Subset: IM |
Affiliation:
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Cellular Function Imaging Laboratory, RIKEN Center for Molecular Imaging Science, Kobe, Hyogo, Japan. cuiyl@riken.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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diagnostic use* Animals Cerebral Cortex / physiopathology*, radionuclide imaging* Cortical Spreading Depression* Immunohistochemistry Isoquinolines / diagnostic use* Male Neurogenic Inflammation / physiopathology*, radionuclide imaging* Positron-Emission Tomography Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/(R)-(11C)1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 0/Amides; 0/Isoquinolines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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