Document Detail


[(11)C]-PIB imaging in patients with Parkinson's disease: preliminary results.
MedLine Citation:
PMID:  17855149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[(11)C]-PIB positron emission tomography ([(11)C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-beta deposition is common in Parkinson's disease (PD) and alpha-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [(11)C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [(11)C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted.
Authors:
A Johansson; I Savitcheva; A Forsberg; H Engler; B Långström; A Nordberg; H Askmark
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-14
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  14     ISSN:  1353-8020     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  345-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital, SE-751 85 Uppsala, Sweden. anders.johansson@neurologi.uu.se
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MeSH Terms
Descriptor/Qualifier:
Aged
Benzothiazoles / metabolism*
Brain Mapping
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Parkinson Disease / radionuclide imaging*
Positron-Emission Tomography / methods*
Chemical
Reg. No./Substance:
0/Benzothiazoles; 0/N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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