| [(11)C]-PIB imaging in patients with Parkinson's disease: preliminary results. | |
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MedLine Citation:
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PMID: 17855149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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[(11)C]-PIB positron emission tomography ([(11)C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-beta deposition is common in Parkinson's disease (PD) and alpha-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [(11)C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [(11)C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted. |
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Authors:
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A Johansson; I Savitcheva; A Forsberg; H Engler; B Långström; A Nordberg; H Askmark |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-14 |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: 14 ISSN: 1353-8020 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-06-02 Completed Date: 2008-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
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Languages: eng Pagination: 345-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital, SE-751 85 Uppsala, Sweden. anders.johansson@neurologi.uu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Benzothiazoles / metabolism* Brain Mapping Female Humans Image Processing, Computer-Assisted Male Middle Aged Parkinson Disease / radionuclide imaging* Positron-Emission Tomography / methods* |
| Chemical | |
Reg. No./Substance:
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0/Benzothiazoles; 0/N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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