Document Detail


The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction.
MedLine Citation:
PMID:  11736957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated plasma von Willebrand factor (VWF) levels are associated with coronary artery disease, although the precise mechanism for this is unclear. Recently, four linked dimorphisms in the VWF gene promoter were demonstrated to influence plasma VWF level. We conducted a case-control study of 525 acute myocardial infarction (MI) cases and 451 control subjects, all aged < or = 75 years, to assess the potential contribution of two of these dimorphisms (-1185 G/A and -1051 A/G) to the risk of MI. The frequency of the -1185A/-1051G haplotype, associated with elevated VWF levels, was similar in the case and control groups, yielding a haplotypic odds ratio for MI of 0.93 (95% CI 0.77, 1.12, P = 0.43), and there was no significant association between the -1185A/-1051G haplotype and the risk of MI in any subgroup analysed. We therefore conclude that possession of the -1185A/-1051G haplotype does not confer an increased risk for MI.
Authors:
R Di Bitondo; C L Cameron; M E Daly; S A Croft; R P Steeds; K S Channer; N J Samani; D Lillicrap; P R Winship
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  115     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  701-6     Citation Subset:  IM    
Affiliation:
Division of Genomic Medicine, Royal Hallamshire Hospital, University of Sheffield, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Female
Haplotypes
Humans
Male
Middle Aged
Myocardial Infarction / blood,  genetics*
Odds Ratio
Polymorphism, Genetic*
Promoter Regions, Genetic*
Risk
Smoking / adverse effects
von Willebrand Factor / genetics*
Chemical
Reg. No./Substance:
0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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