| The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 11736957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Elevated plasma von Willebrand factor (VWF) levels are associated with coronary artery disease, although the precise mechanism for this is unclear. Recently, four linked dimorphisms in the VWF gene promoter were demonstrated to influence plasma VWF level. We conducted a case-control study of 525 acute myocardial infarction (MI) cases and 451 control subjects, all aged < or = 75 years, to assess the potential contribution of two of these dimorphisms (-1185 G/A and -1051 A/G) to the risk of MI. The frequency of the -1185A/-1051G haplotype, associated with elevated VWF levels, was similar in the case and control groups, yielding a haplotypic odds ratio for MI of 0.93 (95% CI 0.77, 1.12, P = 0.43), and there was no significant association between the -1185A/-1051G haplotype and the risk of MI in any subgroup analysed. We therefore conclude that possession of the -1185A/-1051G haplotype does not confer an increased risk for MI. |
| | |
Authors:
|
R Di Bitondo; C L Cameron; M E Daly; S A Croft; R P Steeds; K S Channer; N J Samani; D Lillicrap; P R Winship |
Related Documents
:
|
8076657 - Left ventricular remodelling, neurohormonal activation and early treatment with enalapr... 10519467 - A meta-analysis of psychoeduational programs for coronary heart disease patients. 16002047 - Expression of the multifunctional y-box protein, yb-1, in myofibroblasts of the infarct... 18519547 - Transplanted human cord blood-derived unrestricted somatic stem cells improve left-vent... 23261327 - Pretreatment with xenon protected immature rabbit heart from ischaemia/reperfusion inju... 23530847 - Leptin in heart failure. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of haematology Volume: 115 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2001 Dec |
Date Detail:
|
Created Date: 2001-12-12 Completed Date: 2002-01-07 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
|
Languages: eng Pagination: 701-6 Citation Subset: IM |
Affiliation:
|
Division of Genomic Medicine, Royal Hallamshire Hospital, University of Sheffield, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Case-Control Studies Female Haplotypes Humans Male Middle Aged Myocardial Infarction / blood, genetics* Odds Ratio Polymorphism, Genetic* Promoter Regions, Genetic* Risk Smoking / adverse effects von Willebrand Factor / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/von Willebrand Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Significant linkage and non-linkage of type 1 von Willebrand disease to the von Willebrand factor ge...
Next Document: High prevalence of low serum vitamin B12 in a multi-ethnic Israeli population.