| (111)In-pentetreotide SPET/CT in carcinoid tumours: is the role of hybrid systems advantageous in abdominal or thoracic lesions? | |
| | |
MedLine Citation:
|
PMID: 22087449 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Our aim was to evaluate the different clinical value of (111)In-pentetreotide hybrid SPET/CT versus SPET alone in detecting carcinoid tumours located in the thoracic and abdominal region. Twenty-four patients with carcinoid tumours histologically proven (13 of abdominal origin, 11 of thoracic origin) underwent (111)In-pentetreotide SPET/CT with hybrid system (Millennium VG with Hawkeye, G.E.M.S., USA) composed of a dual head gamma camera equipped with a low dose X-ray tube. Single photon emission tomography images were performed 4h and 24h after (111)In-pentetreotide intravenous administration, while SPET/CT co-registered images were performed at 4h. Scintigraphic images were first evaluated alone and then re-interpreted by adding transmission fused data. Nine of the 13 patients with tumours of abdominal origin showed pathological SPET images, while 4/13 were negative. Seven out of the 11 patients with tumour of thoracic origin had pathological SPET findings, while 4/11 were negative. In all, 11/24 subjects disclosed abdominal pathological uptake and 10/24 thoracic. In 6/11 abdominal cases SPET/CT allowed anatomical localization of lesions, while in 2/10 in thoracic cases. Additional data were provided by SPET/CT in 8/24 cases (6 abdominal, 2 thoracic), by transmission images characterized as lesions not expressing somatostatin receptors. Sensitivity of SPET alone in all carcinoids was 72%, negative predictive value (NPV) was 50% and accuracy was 78%. Considering abdominal lesions (independently of the origin) sensitivity of SPET alone was 64.7%, NPV was 40%, accuracy was 71.4%. For thoracic lesions sensitivity of SPET alone was 83.3%, NPV was 66.7% and accuracy was 87.5%. For SPET/CT considering together all carcinoids and also separately lesions of abdominal and of thoracic origin, sensitivity, NPV and accuracy were always 100%. In conclusion, SPET/CT imaging was more useful to anatomically detect carcinoids either in abdomen or in thorax and specifically lesions not expressing somatostatin receptors, as compared to SPET alone. |
| | |
Authors:
|
Cristina Tranfaglia; Laura Cardinali; Maurizio Gattucci; Michele Scialpi; Piero Ferolla; Helmut Sinzinger; Barbara Palumbo |
Related Documents
:
|
11936059 - Brain abscess following transorbital penetrating injury due to bamboo fragments--case r... 12517619 - Diffusion-weighted mr imaging in the preoperative assessment of brain abscesses. 11932089 - Diverticular abscess presenting as prostate abscess and missed by abdominal ct scan. 21344449 - Sinonasal abnormalities in patients with graves' orbitopathy. 6631519 - Clinical stages of human brain abscesses on serial ct scans after contrast infusion. co... 16163039 - Brain abscess and cystic brain tumor: discrimination with dynamic susceptibility contra... 3990929 - Magnetic resonance imaging: comparative study of radiofrequency pulse techniques in the... 19915849 - Diffusion-weighted mr imaging of liver on 3.0-tesla system: effect of intravenous admin... 12764639 - X-ray imaging of the chest in switzerland in 1998: a nationwide survey. |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Hellenic journal of nuclear medicine Volume: 14 ISSN: 1790-5427 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101257471 Medline TA: Hell J Nucl Med Country: - |
Other Details:
|
Languages: ENG Pagination: 274-277 Citation Subset: - |
Affiliation:
|
Nuclear Medicine Section, University of Perugia, S. Maria della Misericordia Perugia Hospital, S. Andrea Delle Fratte Perugia, Italy. mednuc@unipg.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial scintigraphy, echocardiography and proBNP for early detection of myocardial cardiotoxicit...
Next Document: Quantification and reduction of attenuation related artifacts in SPET by applying attenuation model ...