| 111In-Octreotide Scintigraphy for Identification of Metastatic Medullary Thyroid Carcinoma in Children and Adolescents. | |
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MedLine Citation:
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PMID: 22162469 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Most medullary thyroid cancers (MTC) express somatostatin receptors; therefore, (111)In-octreotide somatostatin receptor scintigraphy (SRS) may be useful in detecting sites of metastases in children with MTC.Objective:The aim of the study was to evaluate tumor metastases in children and adolescents with MTC using SRS in comparison to conventional imaging.Design and Setting:A case series was conducted as part of baseline evaluation for cancer treatment protocol at the National Institutes of Health Clinical Center.Patients:Eleven patients with a median age of 15 (range, 9-17) yr participated in the study, 10 with histologically proven, metastatic MTC due to the M918T mutation of the RET protooncogene, and one with a known RET polymorphism.Intervention:After receiving 0.086 mCi/kg (111)Indium-pentreotide, patients were examined with a single photon emission computed tomography scan 4 and 24 h after injection. Baseline conventional imaging, including computed tomography (neck, chest, abdomen, ± pelvis, adrenals), magnetic resonance imaging (neck), and bone scan, was performed on all patients.Main Outcome Measures:SRS results were compared with conventional imaging.Results:Five of the 11 patients had abnormal findings on SRS. Of the 53 total target lesions present in the patients, only 24.5% were accurately identified through SRS.Conclusions:SRS appears to be less sensitive than conventional imaging at detecting the full extent of metastatic disease in children and adolescents with hereditary MTC. SRS incompletely identified sites of tumor and failed to visualize small sites of tumor or liver and lung metastases, and it has a limited role in the evaluation of metastatic disease in pediatric MTC patients. |
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Authors:
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Maya Lodish; Urania Dagalakis; Clara C Chen; Ninet Sinaii; Patricia Whitcomb; Alberta Aikin; Eva Dombi; Leigh Marcus; Brigitte Widemann; Elizabeth Fox; Meredith Chuk; Frank Balis; Samuel Wells; Constantine A Stratakis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Section on Endocrinology and Genetics (M.L., U.D., C.A.S.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; Department of Nuclear Medicine (C.C.C.), and Biostatistics and Clinical Epidemiology Service (N.S.), National Institutes of Health Clinical Center, Bethesda, Maryland 20892; Pharmacology and Experimental Therapeutics Section (P.W., A.A., E.D., L.M., B.W.), Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892; Children's Hospital of Philadelphia (E.F., F.B.), Division of Oncology, Philadelphia, Pennsylvania 19104; Children's Hospital of Pittsburgh (M.C.), Division of Pediatric Hematology/Oncology, Pittsburgh, Pennsylvania 15224; and Surgery Branch (S.W.), Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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