Document Detail

11 beta-hydroxylase deficiency in hyperandrogenism.
MedLine Citation:
PMID:  2009997     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: to determine the 11-deoxycortisol (S) response and incidence of 11 beta-hydroxylase deficiency in hyperandrogenism. DESIGN: Hyperandrogenic women prospectively and consecutively underwent acute adrenal stimulation studies. SETTING: Tertiary institution. PATIENTS: Two hundred sixty women complaining of hirsutism and/or hyperandrogenic oligomenorrhea were studied, excluding five unrelated families (1.9% of total) suffering from 21-hydroxylase deficient late-onset adrenal hyperplasia. Forty-one healthy premenopausal eumenorrheic women served as controls. MAIN OUTCOME MEASURES: Only two unrelated women (0.8%) had a poststimulation or net increment S level value greater than or equal to threefold the upper 95th percentile of controls and were presumed to suffer from 11 beta-hydroxylase deficient late-onset adrenal hyperplasia. One hundred nine (42%) of hyperandrogenic women had at least one S value above the 95th percentile of controls. These women also demonstrated higher basal (F0) and stimulated cortisol levels, but a similar increment compared with controls. RESULTS: Patients with high S measures had higher testosterone, dehydroepiandrosterone sulfate, and androstenedione levels, but similar luteinizing hormone/follicle-stimulating hormone ratios, than hyperandrogenic cohorts with no abnormal S measures. Basal values of S (S0), F0, or S0/F0 were not useful to predict an abnormal S response to stimulation. CONCLUSIONS: Although adrenocortical hyperactivity was present in 42% of our hyperandrogenic patients, only 0.8% were presumed to suffer from 11 beta-hydroxylase deficient late-onset adrenal hyperplasia. A systemic search for this deficiency in hyperandrogenism is probably unwarranted.
R Azziz; L R Boots; C R Parker; E Bradley; H A Zacur
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Fertility and sterility     Volume:  55     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-03     Completed Date:  1991-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-41     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35294.
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MeSH Terms
Adrenal Glands / pathology
Adrenal Hyperplasia, Congenital*
Androgens / metabolism*
Cortodoxone / pharmacology
Hirsutism / complications
Hormones / blood
Menstruation Disturbances / complications
Predictive Value of Tests
Prospective Studies
Reference Values
Grant Support
Reg. No./Substance:
0/Androgens; 0/Hormones; 152-58-9/Cortodoxone

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