Document Detail

The 100th anniversary of lupus erythematosus tumidus.
MedLine Citation:
PMID:  19162244     Owner:  NLM     Status:  MEDLINE    
In 1909, the term "lupus erythematodes tumidus" was first introduced by the German Dermatologist E. Hoffmann. The next case reports of lupus erythematosus tumidus (LET) were not described until 1930, and in the following years, only a few further cases were reported. This might have been due to the fact that authors have not considered LET as a separate entity different from other variants of cutaneous lupus erythematosus (CLE), and it is likely that skin lesions described under different designations represent the same disease entity. Therefore, LET has been underestimated and neglected in the literature and has been characterized by clinical, histopathological, and immunohistochemical features only in recent years. In particular, phototesting has been crucial in defining LET as a very photosensitive entity of CLE. Up to now, more than 40 reports of LET have been published demonstrating that the course and prognosis of LET are generally more favorable than in other subtypes of CLE. A new classification system, including LET as the intermittent subtype of CLE (ICLE) has been suggested. On the occasion of the 100th anniversary of the first description of LET, we have reviewed the literature and provide here an overview on the different aspects of the disease.
Annegret Kuhn; Dennis Bein; Gisela Bonsmann
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-01-20
Journal Detail:
Title:  Autoimmunity reviews     Volume:  8     ISSN:  1873-0183     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  441-8     Citation Subset:  IM    
Department of Dermatology, University of Münster, Münster, Germany.
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MeSH Terms
Cell Movement
Diagnosis, Differential
History, 20th Century
History, 21st Century
Lupus Erythematosus, Cutaneous* / diagnosis,  epidemiology,  history,  pathology,  physiopathology
Lymphocytes / immunology,  pathology
Photosensitivity Disorders / diagnosis,  epidemiology,  pathology,  physiopathology
Skin / immunology,  pathology

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