Document Detail

A 10-year retrospective study on benzocaine allergy in the United Kingdom.
MedLine Citation:
PMID:  10357712     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Benzocaine has been labeled a notorious sensitizer. It is thought to be a common and potent sensitizer. It is suggested that such patients should routinely avoid tetracaine and procaine, as cross-reactions between benzocaine and such caines occurred commonly. Benzocaine also currently remains the screening chemical on the European Standard Battery (ESB) for topical caine allergy.
OBJECTIVE: To identify the rate of incidence of benzocaine allergy in the United Kingdom, and the level of cross reactivity between other caines in the ESB.
METHODS: The results from a 10-year retrospective study of 5,464 patients, subjected to patch testing with a modified ESB, which included caine mix III (Chemotechnique Diagnostics, Tygelsjo, Sweden), and the results of caine mix IV (Chemotechnique) reactions in 265 of these patients who complained of anogenital symptoms, are discussed.
RESULTS: Majority of allergic reactions occurred with the constituents of caine mix III, with benzocaine reactions being the least common allergen in this group. Cross reactivity between benzocaine and other caines, occurred infrequently.
CONCLUSION: Our data indicate that benzocaine allergy is not common in the United Kingdom. As cross-reactivity between benzocaine and other caines did not occur commonly, a significant number of relevant allergic reactions to other caines may go undetected, as benzocaine remains the screening chemical for topical anaesthetic allergy on the ESB. We suggest benzocaine be removed from the ESB, and be replaced by caine mix III.
S K Sidhu; S Shaw; J D Wilkinson
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society     Volume:  10     ISSN:  1046-199X     ISO Abbreviation:  Am. J. Contact Dermatitis     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-01     Completed Date:  1999-07-01     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9100472     Medline TA:  Am J Contact Dermat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
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MeSH Terms
Anesthetics, Local / adverse effects*
Benzocaine / adverse effects*
Drug Hypersensitivity / epidemiology*,  etiology*,  physiopathology
Great Britain / epidemiology
Patch Tests
Retrospective Studies
Risk Factors
Time Factors
Reg. No./Substance:
0/Anesthetics, Local; 94-09-7/Benzocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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