Document Detail


A 10-year prospective surveillance of nosocomial infections in neonatal intensive care units.
MedLine Citation:
PMID:  17433942     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We report on nosocomial infections (NIs), causative organisms, and antimicrobial susceptibility patterns in neonates who were admitted to neonatal intensive care units (NICUs), and assess the performance of birth weight (BW) as a variable for risk-stratified NI rate reporting. METHODS: A prospective, 10-year follow-up, open cohort study that involved six Brazilian NICUs was conducted. The NI incidence rates were calculated using different denominators. RESULTS: Six thousand two hundred forty-three newborns and 450 NICU-months of data were available for analysis. This included 3603 NIs that occurred in 2286 newborns over 121,008 patient-days. The most frequent NIs were primary bloodstream infection (pBSI; 45.9%), conjunctivitis (12.1%), skin infections (9.6%), and pneumonia (6.8%). Only the pBSI (but not pneumonia or central venous catheter-related pBSI) rate distribution differed significantly with varying BW. Gram-negative rods (mainly Klebsiella sp. and Escherichia coli) were responsible for 51.6% episodes of pBSI. Gram-positive organisms (mainly coagulase-positive staphylococci) accounted for 37.4%. Candida sp. was the fourth isolated organism. A high resistance to third-generation cephalosporins was recorded in K pneumoniae and E coli isolates. CONCLUSIONS: This report highlights the burden of NI, and identifies the major focus for future NI control and prevention programs. Except for pBSI, BW had a poor performance as a variable for risk-stratified NI rate reporting.
Authors:
Renato C Couto; Elaine A A Carvalho; Tânia M G Pedrosa; Enio R Pedroso; Mozar C Neto; Fernando M Biscione
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  American journal of infection control     Volume:  35     ISSN:  0196-6553     ISO Abbreviation:  Am J Infect Control     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-16     Completed Date:  2007-05-15     Revised Date:  2009-08-14    
Medline Journal Info:
Nlm Unique ID:  8004854     Medline TA:  Am J Infect Control     Country:  United States    
Other Details:
Languages:  eng     Pagination:  183-9     Citation Subset:  IM    
Affiliation:
Health Sciences Postgraduate Course, Medicine High School, Minas Gerais Federal University, Belo Horizonte, Minas Gerais, Brazil. renatoccouto@globo.com
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MeSH Terms
Descriptor/Qualifier:
Bacteremia / epidemiology
Brazil / epidemiology
Cross Infection / epidemiology*,  microbiology*
Drug Resistance, Bacterial*
Enterobacteriaceae Infections / epidemiology
Gram-Positive Bacterial Infections / epidemiology
Gram-Positive Cocci / pathogenicity
Humans
Infant, Newborn
Intensive Care Units, Neonatal / statistics & numerical data*
Population Surveillance*
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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