| The 10-year follow-up of a randomised trial of long-chain polyunsaturated fatty acid supplementation in preterm infants: effects on growth and blood pressure. | |
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MedLine Citation:
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PMID: 20515959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that consumption of infant formulas containing long-chain polyunsaturated fatty acids (LCPUFAs) by preterm infants would favourably influence growth, body composition and blood pressure (BP) at age 10 years. METHODS: This was a follow-up study of a preterm cohort (<35 weeks and birth weight <2000 g) randomly assigned to unsupplemented or LCPUFA-supplemented formulas to 9 months post term. The setting was a research clinic at Yorkhill Hospital for Sick Children, Glasgow, UK. A total of 107 children aged 9-11 years who participated in the original randomised controlled trial (45% follow-up) took part. Main outcome measures were: (1) anthropometry, (2) body composition and (3) BP. RESULTS: There were no differences in growth or BP between randomised groups for the whole cohort. However, girls who had received LCPUFA-supplemented formula were heavier (42.20 (SD 9.61) vs 36.94 (9.46) kg, p=0.05), had greater skin fold thicknesses (biceps 10.7 (3.3) vs 8.5 (3.6) mm, p=0.03; suprailiac 16.7 (8.2) vs 12.0 (7.5) mm, p=0.03) and higher BP (mean 82.2 (8.4) vs 78.1 (6.2) mm Hg, p=0.04: systolic 111.4 (10.1) vs 105.9 (9.0) mm Hg, p=0.04: diastolic 64.8 (8.4) vs 61.1 (5.4) mm Hg, p=0.05). Differences in weight SD score (0.85 (95% CI 0.13 to 1.58), p=0.02), Ln sum of skin fold thicknesses (0.27 (0.02 to 0.52), p=0.04) and BP (mean 4.6 mm Hg (0.43 to 8.84), p=0.03; systolic 6.1 (0.45 to 11.7), p=0.04) remained after adjustment for prerandomisation confounders. Differences in BP were not significant following adjustment for current weight. CONCLUSIONS: Girls born preterm and randomised to LCPUFA-supplemented formula showed increased weight, adiposity and BP at 9-11 years, which might have adverse consequences for later health. No effects were seen in boys. Long-term follow-up of other LCPUFA supplementation trials is required to further investigate this finding. |
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Authors:
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Kathy Kennedy; Sarah Ross; Elizabeth B Isaacs; Lawrence T Weaver; Atul Singhal; Alan Lucas; Mary S Fewtrell |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: Archives of disease in childhood Volume: 95 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-10-06 Revised Date: 2011-01-31 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: England |
Other Details:
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Languages: eng Pagination: 588-95 Citation Subset: AIM; IM |
Affiliation:
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MRC Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK. k.kennedy@ich.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anthropometry
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methods Blood Pressure / drug effects Body Composition / drug effects Body Weight / drug effects Dietary Fats, Unsaturated / pharmacology Fatty Acids, Unsaturated / pharmacology* Female Follow-Up Studies Food, Fortified Growth / drug effects*, physiology Humans Infant Food* Infant Nutritional Physiological Phenomena / physiology* Infant, Newborn Infant, Premature / physiology* Male Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated |
| Comments/Corrections | |
Comment In:
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Arch Dis Child. 2011 Feb;96(2):205-6; author reply 206-7
[PMID:
20870627
]
Arch Dis Child. 2011 Feb;96(2):206; author reply 206-7 [PMID: 20880943 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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