Document Detail

10-undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability.
MedLine Citation:
PMID:  19493009     Owner:  NLM     Status:  MEDLINE    
Undecanoic acid (UDA) is a fatty acid with significant antimycotic activity. In this work we have synthesized 10-undecanhydroxamic acid, a hydroxamate derivative of the UDA, and tested its antimicrobial activity on different microorganisms. Our results demonstrate that this compound has higher efficacy than UDA against a variety of fungi and bacteria. Analysis of the intracellular concentration of protein involved in iron transport in Salmonella enterica serovar Typhimurium suggests that its antimicrobial effect actually relies on the ability to chelate iron ions, providing an efficient mechanism to interfere with microbial growth.
Serena Ammendola; Angelo Lembo; Andrea Battistoni; Pietro Tagliatesta; Carlo Ghisalberti; Alessandro Desideri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-18
Journal Detail:
Title:  FEMS microbiology letters     Volume:  294     ISSN:  1574-6968     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-04     Completed Date:  2009-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  61-7     Citation Subset:  IM    
Dipartimento di Biologia, Università di Roma Tor Vergata, Rome, Italy.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis,  pharmacology*
Bacteria / drug effects*
Chelating Agents / chemical synthesis,  pharmacology*
Fungi / drug effects*
Hydroxamic Acids / chemical synthesis,  pharmacology*
Iron / antagonists & inhibitors*
Salmonella typhimurium / metabolism
Reg. No./Substance:
0/10-undecanhydroxamic acid; 0/Anti-Bacterial Agents; 0/Chelating Agents; 0/Hydroxamic Acids; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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