| 10-Undecynoic acid, an inhibitor of cytochrome P450 4A1, inhibits ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes. | |
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MedLine Citation:
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PMID: 10453996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1,12-Dodecanedioic acid, the end-product of omega-hydroxylation of lauric acid, stimulates in a concentration dependent manner, phosphatidylethanolamine synthesis via ethanolamine-specific phospholipid base exchange reaction in rat liver endoplasmic reticulum. On the other hand, administration to rats of 10-undecynoic acid, a specific inhibitor of omega-hydroxylation reaction catalyzed by cytochrome P450 4A1, inhibits the ethanolamine-specific phospholipid base exchange activity by 30%. This is accompanied by a small but significant decrease in phosphatidylethanolamine content in the endoplasmic reticulum and inhibition of cytochrome P450 4A1. On the basis of these results it can be proposed that a functional relationship between cytochrome P450 4A1 and phosphatidylethanolamine synthesis exists in rat liver. Cytochrome P450 4A1 modulates the cellular level of lauric acid, an inhibitor of phospholipid synthesis. In turn, ethanolamine-specific phospholipid base exchange reaction provides molecular species of phospholipids, containing mainly long-chain polyunsaturated fatty acid moieties, required for the optimal activity of cytochrome P450 4A1. |
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Authors:
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J Lenart; S Pikuła |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta biochimica Polonica Volume: 46 ISSN: 0001-527X ISO Abbreviation: Acta Biochim. Pol. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-09-30 Completed Date: 1999-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 14520300R Medline TA: Acta Biochim Pol Country: POLAND |
Other Details:
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Languages: eng Pagination: 203-10 Citation Subset: IM |
Affiliation:
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Department of Cellular Biochemistry, M. Nencki Institute of Experimental Biology, Warszawa, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkane 1-Monooxygenase Animals Cytochrome P-450 Enzyme System / antagonists & inhibitors* Enzyme Inhibitors / pharmacology* Fatty Acids, Unsaturated / pharmacology* Male Microsomes, Liver / drug effects*, enzymology Mixed Function Oxygenases / antagonists & inhibitors* Phosphatidylethanolamines / metabolism* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Fatty Acids, Unsaturated; 0/Phosphatidylethanolamines; 2777-65-3/10-undecynoic acid; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases; EC 1.14.15.3/Alkane 1-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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