Document Detail

A 1-y trial of the effect of high-selenium bread on selenium concentrations in blood and toenails.
MedLine Citation:
PMID:  8438776     Owner:  NLM     Status:  MEDLINE    
The concentration of selenium in toenail clippings and blood reflects dietary intake better than does intake calculated from dietary data because of the highly variable selenium concentration in different samples of the same food. However, the time course of selenium intake in relation to subsequent concentrations in toenail clippings is unclear. Therefore, 12 males were fed high-dose (4.91 mumol Se/d), medium-dose (2.61 mumol Se/d), or control (0.41 mumol Se/d) whole-wheat-bread for 1 y and the concentration of selenium was measured in toenail clippings collected every 12 wk for 2 y. Toenail selenium concentration was unaffected by dietary intake in the previous 3 mo and appeared to provide a time-integrated measure of intake over a period of 26-52 wk. Use of selenium concentration in toenail clippings may be an alternative to blood when a measure of long-term average intake is desired. The absence of a short-term effect of diet on toenail selenium concentration also makes this a useful marker of intake in retrospective studies.
M P Longnecker; M J Stampfer; J S Morris; V Spate; C Baskett; M Mason; W C Willett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  57     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-03-25     Completed Date:  1993-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  408-13     Citation Subset:  AIM; IM    
Department of Epidemiology, University of California, Los Angeles School of Public Health 90024-1772.
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MeSH Terms
Middle Aged
Nails / metabolism*
Selenium / administration & dosage*,  blood,  pharmacokinetics*
Reg. No./Substance:

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