Document Detail


ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury.
MedLine Citation:
PMID:  23408710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: ASC-mediated caspase-1/IL-1β signaling promotes HMGB1 to produce a TLR4-dependent inflammatory phenotype and leads to hepatocellular injury. Hence, ASC/caspase-1/IL-1β signaling mediates the inflammatory response by triggering HMGB1 induction in hepatic IRI. Our findings provide a rationale for a novel therapeutic strategy for managing liver injury due to IR.
Authors:
Naoko Kamo; Bibo Ke; Amir A Ghaffari; Xiu-da Shen; Ronald W Busuttil; Genhong Cheng; Jerzy W Kupiec-Weglinski
Publication Detail:
Type:  Journal Article     Date:  2013-05-15
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Caspase 1 / physiology*
Cytoskeletal Proteins / deficiency,  physiology*
HMGB1 Protein / biosynthesis*
Interleukin-1beta / physiology*
Liver / injuries
Male
Mice
Mice, Knockout
Reperfusion Injury / immunology*,  prevention & control
Signal Transduction / physiology
Toll-Like Receptor 4 / physiology
Grant Support
ID/Acronym/Agency:
R01 DK062357/DK/NIDDK NIH HHS; T32 GM008042/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/HMGB1 Protein; 0/HMGB1 protein, mouse; 0/Interleukin-1beta; 0/Pycard protein, mouse; 0/Tlr4 protein, mouse; 0/Toll-Like Receptor 4; EC 3.4.22.36/Caspase 1
Comments/Corrections
Comment In:
Hepatology. 2013 Dec;58(6):2212-3   [PMID:  23696070 ]
Hepatology. 2013 Dec;58(6):2212   [PMID:  23696239 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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