Document Detail


Morgana/CHP-1 is a novel chaperone able to protect cells from stress.
MedLine Citation:
PMID:  20493909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Morgana/CHP-1 (CHORD containing protein-1) has been recently shown to be necessary for proper cell divisions. However, the presence of the protein in postmitotic tissues such as brain and striated muscle suggests that morgana/CHP-1 has additional cellular functions. Here we show that morgana/CHP-1 behaves like an HSP90 co-chaperone and possesses an independent molecular chaperone activity towards denatured proteins. The expression time profile of morgana/Chp-1 in NIH3T3 cells in response to heat stress is similar to that of Hsp70, a classical effector of Heat Shock Factor-1 mediated stress response. Moreover, overexpression of morgana/CHP-1 in NIH3T3 cells leads to the increased stress resistance of the cells. Interestingly, morgana/Chp-1 upregulation in response to transient global brain ischemia lasts longer in ischemia-resistant regions of the gerbil hippocampus than in vulnerable ones, suggesting the involvement of morgana/CHP-1 in natural protective mechanisms in vivo.
Authors:
Wojciech Michowski; Roberta Ferretti; Marta B Wisniewska; Mateusz Ambrozkiewicz; Malgorzata Beresewicz; Federica Fusella; Anna Skibinska-Kijek; Barbara Zablocka; Mara Brancaccio; Guido Tarone; Jacek Kuznicki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-20
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1803     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1043-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
International Institute of Molecular and Cell Biology; ul. Ks. Trojdena 4, 02-109 Warsaw, Poland. Wojciech_Michowski@dfci.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / genetics,  pathology
Carrier Proteins / genetics,  physiology*
Cells / metabolism*
Cells, Cultured
Cytoprotection / genetics*
Gerbillinae
HSP90 Heat-Shock Proteins / metabolism,  physiology
Heat-Shock Response / genetics,  physiology
Hot Temperature
Mice
Molecular Chaperones / genetics,  physiology
NIH 3T3 Cells
Stress, Physiological / genetics*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Chp-1 protein, mouse; 0/HSP90 Heat-Shock Proteins; 0/Molecular Chaperones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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