Document Detail

1 kgf/cm2--the isometric tension of muscle contraction: implications to cross-bridge and hydraulic mechanisms.
MedLine Citation:
PMID:  6234756     Owner:  NLM     Status:  MEDLINE    
Attention is drawn to experimental results from many laboratories which indicate that the isometric force (F) in the contraction of striated muscle fibers is linearly proportional to their variable cross-section area (A). Reversible swelling of intact, skinned, or glycinerated fibers can be induced by changes in tonicity, ionic strength or pH. In all cases where careful measurements of F and A are reported, the maximal isometric tension namely, T = F/A, is found around 1 kgf /cm2, even though F and A may change more than threefold for a given fiber at a certain length. These results seem to be independent of the fiber length or temperature. Thus, the isometric tension T in striated muscle does not depend on the number or the rate of the interacting cross-bridges. This result of constant isometric tension, which has so far received little attention, is however, a simple prediction of the hydraulic mechanism which is proposed for muscle contraction. Therefore, the hydraulic model, which is based on the hypothesis of vectorial flux of energetic protons deserves serious consideration.
R Tirosh
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  170     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-07-27     Completed Date:  1984-07-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-9     Citation Subset:  IM    
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MeSH Terms
Actins / metabolism
Adenosine Triphosphatases / metabolism
Adenosine Triphosphate / pharmacology
Isometric Contraction*
Models, Biological
Muscle Contraction*
Muscles / physiology*
Myofibrils / physiology*
Myosin Subfragments / metabolism
Myosins / metabolism
Reg. No./Substance:
0/Actins; 0/Myosin Subfragments; 56-65-5/Adenosine Triphosphate; EC 3.6.1.-/Adenosine Triphosphatases; EC

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